| Computational fluid dynamics analysis of thrombosis potential in left ventricular assist device drainage cannulae. | |
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MedLine Citation:
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PMID: 20400890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cannulation is necessary when blood is removed from the body, for example in hemodialysis, cardiopulmonary bypass, blood oxygenators, and ventricular assist devices. Artificial blood contacting surfaces are prone to thrombosis, especially in the presence of stagnant or recirculating flow. In this work, computational fluid dynamics was used to investigate the blood flow fields in three clinically available cannulae (Medtronic DLP 12, 16, and 24 F), used as drainage for pediatric circulatory support and to calculate parameters that may be indicative of thrombosis potential. The results show that using the 24 F cannula below flow rates of about 0.75 L/min produces hemodynamic conditions, which may increase the risk of blood clotting within the cannula. No reasons are indicated for not using the 12 or 16 F cannulae with flow rates between 0.25 and 3.0 L/min. |
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Authors:
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Katharine H Fraser; Tao Zhang; M Ertan Taskin; Bartley P Griffith; Zhongjun J Wu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 56 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-08-10 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 157-63 Citation Subset: IM |
Affiliation:
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Department of Surgery, Artificial Organs Laboratory, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiopulmonary Bypass Catheterization / instrumentation* Child Drainage Heart Ventricles / physiopathology Heart-Assist Devices* Hemodynamics Humans Risk Factors Thrombosis / therapy |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL088100-01A2/HL/NHLBI NIH HHS; R01 HL088100-02/HL/NHLBI NIH HHS; R01HL088100/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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