| Computation models simulating notochordal cell extinction during early ageing of an intervertebral disc. | |
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MedLine Citation:
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PMID: 21424951 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lower back pain due to intervertebral disc (IVD) degeneration is a prevalent problem which drastically affects the quality of life of millions of sufferers. Healthy IVDs begin with high populations of notochordal cells in the nucleus pulposus, while by the second stage of degeneration, these cells will be replaced by chondrocyte-like cells. Because the IVD is avascular, these cells rely on passive diffusion of nutrients to survive. It is thought that this transition in cell phenotype causes the shift of the IVD's physical properties, which impede the flow of nutrients. Our computational model of the IVD illustrates its ability to simulate the evolving chemical and mechanical environments occurring during the early ageing process. We demonstrate that, due to the insufficient nutrient supply and accompanying changes in physical properties of the IVD, there was a resultant exponential decay in the number of notochordal cells over time. |
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Authors:
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K M Louman-Gardiner; D Coombe; C J Hunter |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-01 |
Journal Detail:
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Title: Computer methods in biomechanics and biomedical engineering Volume: - ISSN: 1476-8259 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9802899 Medline TA: Comput Methods Biomech Biomed Engin Country: - |
Other Details:
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Languages: ENG Pagination: 1 Citation Subset: - |
Affiliation:
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Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alta., Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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