Document Detail

Compulsive behaviors in patients with Parkinson's disease.
MedLine Citation:
PMID:  20445429     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Several impulse control disorders (ICDs) may develop in patients with Parkinson's disease (PD). We aimed to identify the frequency and phenomenology of ICDs in our PD population.
METHODS: Among 554 PD patients examined in a 3-year period, we identified 33 patients with ICDs. Disease duration, gender, and age-matched 65 PD patients without ICDs were selected as controls. We noted age-at-onset, duration, and severity of PD, dose and types of dopaminergic treatment, as well as presence of motor complications in both groups.
RESULTS: Of 554 patients, 33 (5.9%) had ICDs, of whom, 27 were men (81%), mean age-at onset of PD was 48 and disease duration 8 years. While all patients with ICDs were on dopamine agonist drugs (+/- an adjuvant), all but 2 of controls were on dopamine agonists. Punding was the most frequent behavioral problem (57%), 42% exhibited aggressive hypersexuality, 27% compulsive eating, 24% pathologic shopping, and 21% compulsive medication. Severity of PD, presence of l-Dopa-induced motor complications, l-Dopa equivalent doses of dopamine agonists administered were not statistically different between 2 groups.
CONCLUSIONS: In this study performed in a tertiary clinic for movement disorders in Turkey, several ICDs occurred in a small group of PD patients, mostly in men with young-onset disease, similar to the previous reported series. However, in contrast to the Western series, the number of gamblers was quite low because gambling is illegal in our country. We did not find any association between ICDs and severity of PD as well as doses of dopaminergic agents.
Gülay Kenangil; Sibel Ozekmekçi; Melis Sohtaoglu; Ethem Erginöz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The neurologist     Volume:  16     ISSN:  2331-2637     ISO Abbreviation:  Neurologist     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-09     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-5     Citation Subset:  IM    
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MeSH Terms
Antiparkinson Agents / administration & dosage,  adverse effects*
Binge-Eating Disorder / chemically induced,  epidemiology,  physiopathology
Brain / drug effects,  metabolism,  physiopathology
Dopamine / metabolism
Dopamine Agonists / administration & dosage,  adverse effects
Dose-Response Relationship, Drug
Gambling / psychology
Mental Disorders / chemically induced,  epidemiology,  physiopathology
Middle Aged
Obsessive-Compulsive Disorder / chemically induced*,  epidemiology*,  physiopathology
Parkinson Disease / drug therapy*,  epidemiology*
Risk Factors
Sexual Dysfunction, Physiological / chemically induced,  epidemiology,  physiopathology
Substance-Related Disorders / epidemiology,  physiopathology
Reg. No./Substance:
0/Antiparkinson Agents; 0/Dopamine Agonists; VTD58H1Z2X/Dopamine

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