Document Detail

Compulsive activity and anterograde amnesia after zolpidem use.
MedLine Citation:
PMID:  17364638     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Zolpidem is a selective GABAAalpha1 receptor modulator used for its hypnotic-sedative properties. Zolpidem has side effects that are similar but not identical to the benzodiazepines. We report the first cases of compulsive activity combined with anterograde amnesia after the use of zolpidem. CASE REPORT: Three women experienced anterograde amnesia and compulsive repetitive behaviors after zolpidem use. These activities consisted of cleaning, shopping, and eating. These behaviors stopped after discontinuation of the zolpidem. CONCLUSION: These reports demonstrate that compulsive activity combined with anterograde amnesia may be associated with the use of zolpidem. Physicians and pharmacists should be aware of this potential side effect.
Ming-Jun Tsai; Yi-Hung Tsai; Yaw-Bin Huang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  45     ISSN:  1556-3650     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-03-29     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-81     Citation Subset:  AIM; IM    
Institute of Basic Medical Sciences, National Cheng Kung University, Tinan City, Taiwan.
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MeSH Terms
Amnesia, Anterograde / chemically induced*
Compulsive Behavior / chemically induced*
Hypnotics and Sedatives / administration & dosage,  adverse effects*,  therapeutic use
Pyridines / administration & dosage,  adverse effects*,  therapeutic use
Sleep Initiation and Maintenance Disorders / drug therapy
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Pyridines; 82626-48-0/zolpidem

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