Document Detail

Compromised bone healing following spacer removal in a rat femoral defect model.
MedLine Citation:
PMID:  22849847     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The clinical demand for bone grafting materials necessitated the development of animal models. Critical size defect model has been criticized recently, mainly for its inaccuracy. Our objective was to develop a dependable animal model that would provide compromised bone healing, and would allow the investigation of bone substitutes.
METHODS: In the first group a critical size defect was created in the femur of adult male Wistar rats, and a non-critical defect in the remaining animals (Groups II, III and IV). The defect was left empty in group II, while in groups III and IV a spacer was interposed into the gap. Osteoblast activity was evaluated by NanoSPECT/CT imaging system. New bone formation and assessment of a union or non-union was observed by μCT and histology.
RESULTS: The interposition model proved to be highly reproducible and provided a bone defect with compromised bone healing. Significant bone regeneration processes were observed four weeks after removal of the spacer.
CONCLUSION: Our results have shown that when early bone healing is inhibited by the physical interposition of a spacer, the regeneration process is compromised for a further 4 weeks and results in a bone defect during the time-course of the study.
Gábor Skaliczki; M Weszl; K Schandl; T Major; M Kovács; J Skaliczki; H Redl; M Szendrői; K Szigeti; D Máté; Cs Dobó-Nagy; Zs Lacza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  99     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-09-06     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  223-32     Citation Subset:  IM    
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MeSH Terms
Bone Regeneration
Disease Models, Animal
Femoral Fractures / pathology*,  physiopathology
Femur / pathology*,  physiopathology,  surgery
Fracture Healing*
Fractures, Ununited / pathology*,  physiopathology
Multimodal Imaging / methods
Osteoblasts / pathology*
Positron-Emission Tomography
Rats, Wistar
Time Factors
Tomography, X-Ray Computed
X-Ray Microtomography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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