| Comprehensive imaging of tumor recurrence in breast cancer patients using whole-body MRI at 1.5 and 3 T compared to FDG-PET-CT. | |
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MedLine Citation:
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PMID: 18082989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the diagnostic accuracy for the detection of tumor recurrence in breast cancer patients using whole-body-MRI (WB-MRI) at 1.5 or 3T compared to FDG-PET-CT. MATERIALS AND METHODS: Thirty-three female patients with breast cancer and suspicion of recurrence underwent FDG-PET-CT and WB-MRI. Coronal T1w-TSE- and STIR-sequences, HASTE-imaging of the lungs, contrast-enhanced T1w- and T2w-TSE-sequences of the liver, brain and abdomen were performed, using a WB-MRI-scanner at 1.5 (n=23) or 3T (n=10). Presence of local recurrence, lymph node involvement and distant metastatic disease was assessed using clinical and radiological follow-up as a standard of reference. RESULTS: Tumor recurrence was found in 20 of 33 patients. Overall 186 malignant foci were detected with WB-MRI and PET-CT. Both modalities revealed two recurrent tumors of the breast. PET-CT detected more lymph node metastases (n=21) than WB-MRI (n=16). WB-MRI was more precise in the detection of distant metastases (n=154 versus n=147). Sensitivity was 93% (172/186) and 91% (170/186) for WB-MRI and PET-CT, specificity was 86% (66/77) and 90% (69/77), respectively. Examination times for WB-MRI at 1.5 and 3T were 51 and 43 min, respectively, examination time for PET-CT was 103 min. CONCLUSION: WB-MRI and PET-CT are useful for the detection of tumor recurrence in the follow-up of breast cancer. WB-MRI is highly sensitive to distant metastatic disease. PET-CT is more sensitive in detecting lymph node involvement. Tumor screening with WB-MRI is feasible at 1.5 and 3T, scan time is further reduced at 3T with identical resolution. |
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Authors:
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Gerwin P Schmidt; Andrea Baur-Melnyk; Alexander Haug; Volker Heinemann; Ingo Bauerfeind; Maximilian F Reiser; Stefan O Schoenberg |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-12-20 |
Journal Detail:
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Title: European journal of radiology Volume: 65 ISSN: 0720-048X ISO Abbreviation: Eur J Radiol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-08 Completed Date: 2008-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 47-58 Citation Subset: IM |
Affiliation:
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Institute of Clinical Radiology, University Hospitals Munich-Grosshadern, Marchioninistr. 15, 81377 Munich, Germany. gerwin.schmidt@med.uni-muenchen.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Neoplasms / diagnosis*, radiography, radionuclide imaging Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use Humans Image Interpretation, Computer-Assisted Iohexol / analogs & derivatives, diagnostic use Lymphatic Metastasis Magnetic Resonance Imaging / methods* Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local / diagnosis* Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Tomography, Emission-Computed Tomography, X-Ray Computed / methods* Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18; 66108-95-0/Iohexol; 73334-07-3/iopromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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