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Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultrasmall superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO2) nanoparticles in rats.
MedLine Citation:
PMID:  23272807     Owner:  NLM     Status:  Publisher    
Abstract As a main excretory organ kidney is predisposed to direct/indirect injury. We addressed the potential nephrotoxic effects following expositions of healthy rats to nanoparticles (NPs)-loads relevant to humans in a situation of 100% bioavailability. Up to 4 weeks after administration, a single i.v. bolus of oleate-coated ultra-small superparamagnetic iron oxide NPs (in dose of 0.1%, 1.0% and 10.0% of LD50) or TiO2 nanoparticles (1.0% of LD50) did not elicit decline in renal function, damage to proximal tubules, alterations in: renal histology or expression of pro-inflammatory/pro-fibrotic genes, markers of systemic or local renal microinflammation or oxidative damage. Antioxidant enzymes activities in renal cortex, mildly elevated at 24 h, completely restored at later time points. Data obtained by multifaceted approach enable the prediction of human nephrotoxicity during preclinical studies, and may serve as comparison for alternative testing strategies using in vitro and in silico methods essential for the NPs-nephrotoxicity risk assessment.
Katarina Sebekova; Maria Dusinska; Kristina Simon Klenovics; Radana Kollarova; Peter Boor; Anton Kebis; Marta Staruchova; Barbora Vlkova; Peter Celec; Julius Hodosy; Ladislav Baciak; Radka Tuskova; Milan Beno; Jana Tulinska; Jana Pribojova; Dagmar Bilanicova; Giulio Pojana; Antonio Marcomini; Katarina Volkovova
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  Nanotoxicology     Volume:  -     ISSN:  1743-5404     ISO Abbreviation:  Nanotoxicology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233132     Medline TA:  Nanotoxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Comenius University Medical Faculty, Inst. Molecular Biomedicine, Sasinkova 4, Bratislava, (State), Slovakia, 81108.
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