Document Detail

Comprehensive analysis of exertional ECG changes before and after oral propranolol.
MedLine Citation:
PMID:  262576     Owner:  NLM     Status:  MEDLINE    
In 12 patients with symptomatic coronary heart disease and three normal persons, comprehensive analyses of the electrocardiographic changes associated with symptom-limited upright exercise are made by computer analysis of the electrocardiogram recorded using a Frank XYZ lead system. This analysis provided a display of the 12 lead ECG, vectorcardiogram, polarcardiogram, and spatial cardiogram and measurements of spatial magnitudes of heart vectors. The effect of 40 mg of oral propranolol was assessed by repeating the exercise protocol 60--90 min later. There is evidence that propranolol reduces the electrocardiographic features of myocardial ischemia. This reduction in myocardial ischemia correlates with reductions in pressure rate product and heart rate. The presence of infarct criteria with exercise is variable and not apparently influenced by propranolol.
K F Hossack; R A Bruce; F Kusumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical cardiology     Volume:  2     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-80     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Coronary Disease / diagnosis*
Depression, Chemical
Exercise Test*
Heart / drug effects*
Heart Rate / drug effects
Middle Aged
Propranolol / pharmacology*
Reg. No./Substance:

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