Document Detail

Comprehensive analysis of Alu-associated diversity on the human sex chromosomes.
MedLine Citation:
PMID:  14604797     Owner:  NLM     Status:  MEDLINE    
A comprehensive analysis of the human sex chromosomes was undertaken to assess Alu-associated human genomic diversity and to identify novel Alu insertion polymorphisms for the study of human evolution. Three hundred forty-five recently integrated Alu elements from eight different Alu subfamilies were identified on the X and Y chromosomes, 225 of which were selected and analyzed by polymerase chain reaction (PCR). From a total of 225 elements analyzed, 16 were found to be polymorphic on the X chromosome and one on the Y chromosome. In line with previous research using other classes of genetic markers, our results indicate reduced Alu-associated insertion polymorphism on the human sex chromosomes, presumably reflective of the reduced recombination rates and lower effective population sizes on the sex chromosomes. The Alu insertion polymorphisms identified in this study should prove useful for the study of human population genetics.
Pauline A Callinan; Dale J Hedges; Abdel-Halim Salem; Jinchuan Xing; Jerilyn A Walker; Randall K Garber; W Scott Watkins; Michael J Bamshad; Lynn B Jorde; Mark A Batzer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gene     Volume:  317     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-01-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  103-10     Citation Subset:  IM    
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA.
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MeSH Terms
Alu Elements / genetics*
Cell Line
Chromosome Mapping
Chromosomes, Human, X / genetics*
Chromosomes, Human, Y / genetics*
Evolution, Molecular*
Gene Dosage
Genetic Variation
Genome, Human
Hela Cells
Time Factors
Grant Support

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