| Comprehensive allelotyping of hepatoblastoma. | |
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MedLine Citation:
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PMID: 19453057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Hepatoblastoma is the most common malignant liver tumor to affect young children. METHODOLOGY: To identify loci of potential tumor suppressor genes, associated with HB, we carried out a genome-wide allelotyping study in panel of 15 HBs using 67 highly polymorphic microsatellite markers including 14 known tumor suppressor gene loci. RESULTS: Allelic losses at microsatellite loci were frequent on 1q (73.3%), 4q (26.7%), 13q (73.3%), 17p (46.7%), and 17q (86.7%). Deletion mapping of these chromosome arms localized commonly deleted regions to 1q44, 4q21-22, 13q14 (containing Rb1), 17p13 (containing TP53), and 17q11.2 (containing NF1). CONCLUSIONS: Allelic losses at multiple loci may implicate chromosomal instability as an important factor in development and progression of HB. |
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Authors:
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Yoshie Terada; Satoshi Matsumoto; Kouichi Bando; Takashi Tajiri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 56 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-05-20 Completed Date: 2009-06-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alleles Child Child, Preschool Chromosome Deletion Chromosome Mapping Female Genes, Tumor Suppressor Genotype Hepatoblastoma / genetics* Humans Infant Liver Neoplasms / genetics* Loss of Heterozygosity* / genetics Male Microsatellite Repeats |
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