Document Detail


Comprehensive allelotyping of hepatoblastoma.
MedLine Citation:
PMID:  19453057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Hepatoblastoma is the most common malignant liver tumor to affect young children. METHODOLOGY: To identify loci of potential tumor suppressor genes, associated with HB, we carried out a genome-wide allelotyping study in panel of 15 HBs using 67 highly polymorphic microsatellite markers including 14 known tumor suppressor gene loci. RESULTS: Allelic losses at microsatellite loci were frequent on 1q (73.3%), 4q (26.7%), 13q (73.3%), 17p (46.7%), and 17q (86.7%). Deletion mapping of these chromosome arms localized commonly deleted regions to 1q44, 4q21-22, 13q14 (containing Rb1), 17p13 (containing TP53), and 17q11.2 (containing NF1). CONCLUSIONS: Allelic losses at multiple loci may implicate chromosomal instability as an important factor in development and progression of HB.
Authors:
Yoshie Terada; Satoshi Matsumoto; Kouichi Bando; Takashi Tajiri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  56     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Affiliation:
Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alleles
Child
Child, Preschool
Chromosome Deletion
Chromosome Mapping
Female
Genes, Tumor Suppressor
Genotype
Hepatoblastoma / genetics*
Humans
Infant
Liver Neoplasms / genetics*
Loss of Heterozygosity* / genetics
Male
Microsatellite Repeats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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