Document Detail

Comprehensive evaluation and medical management of infrainguinal peripheral artery disease: "when to treat, when not to treat".
MedLine Citation:
PMID:  20123428     Owner:  NLM     Status:  MEDLINE    
Peripheral artery disease (PAD) is a highly prevalent atherosclerotic syndrome associated with significant morbidity and mortality. PAD is defined by atherosclerotic obstruction of the arteries to the legs that reduce arterial flow during exercise or at rest, and is associated with systemic atherosclerosis. The clinical presentation of PAD is quite varied, including patients with atypical leg symptoms, classic intermittent claudication, and critical limb ischemia. Clinical assessment of these patients includes a comprehensive history, physical examination, and noninvasive and invasive vascular studies. The major risk factors for PAD include diabetes mellitus, tobacco abuse, hyperlipidemia, hypertension, and advanced age. Because of the presence of these risk factors, the systemic nature of atherosclerosis, and the high risk of ischemic events, patients with PAD should be candidates for comprehensive secondary prevention strategies, including aggressive glycemic control, all attempts at tobacco cessation, lipid lowering and antihypertensive treatment, antiplatelet therapy, and thorough foot care. This article reviews the comprehensive diagnostic algorithm and medical treatment strategies for patients with infrainguinal PAD.
Thomas J Kiernan; Brian G Hynes; Nicholas J Ruggiero; Bryan P Yan; Michael R Jaff
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Techniques in vascular and interventional radiology     Volume:  13     ISSN:  1557-9808     ISO Abbreviation:  Tech Vasc Interv Radiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806675     Medline TA:  Tech Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-10     Citation Subset:  IM    
Section of Vascular Medicine, Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA.
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MeSH Terms
Angiography, Digital Subtraction
Arterial Occlusive Diseases / complications,  diagnosis,  therapy*
Clinical Protocols
Constriction, Pathologic
Intermittent Claudication / etiology,  therapy
Ischemia / etiology,  therapy
Lower Extremity / blood supply*
Magnetic Resonance Angiography
Patient Selection*
Peripheral Vascular Diseases / complications,  diagnosis,  therapy*
Predictive Value of Tests
Risk Assessment
Risk Factors
Secondary Prevention
Tomography, X-Ray Computed
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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