Document Detail

Comprehensive assessment of aortic compliance and brachial endothelial function using 3.0-T high-resolution MRI: a feasibility study.
MedLine Citation:
PMID:  22805674     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the feasibility of one-stop examination of aortic pulse wave velocity (PWV) , aortic distensibility (AD), and brachial artery flow-mediated dilation (FMD) in healthy volunteers by means of 3.0-T high-resolution magnetic resonance imaging (MRI).
METHODS: A total of 32 healthy volunteers (24-37 years old; mean age, 29 years) underwent repeated high-resolution MRI to assess aortic PWV, ascending aorta (AA) AD, proximal descending aorta (PDA) AD, distal descending aorta (DDA) AD, and FMD of the brachial artery with an interval of 1 to 2 hours. Pulse wave velocity was evaluated by 2-dimensional (2D) phase contrast velocity-encoded MRI with a 4.7- to 7.8-millisecond (ms) temporal resolution. Fiesta-cine MRI was used to assess AD and FMD with a 18.75- to 31.25-ms temporal resolution. The image quality of repeated scans was evaluated with 4-point scores, and the agreement between the 2 scans was tested with kappa analysis. The reproducibility of the results from repeated measurements for PWV, AA-AD, PDA-AD, DDA-AD, and FMD was assessed with intraclass correlation coefficient (ICC) analysis. The method of Bland-Altman plot was also used to assess the agreement between repeated measurements.
RESULTS: Each examination including PWV, AD, and FMD were completed in approximately half an hour. The image quality between repeated scans showed good agreement (κ value, 0.776) with a mean score of 3.53 and 3.41, respectively. Reproducibility between repeated measurements was high for aortic PWV (4.33 ± 0.88 vs 4.36 ± 0.88 m/s; ICCPWV = 0.95; P < 0.01), AA-AD (8.60 ± 3.11 vs 8.59 ± 3.10 × 10⁻³ mm Hg⁻¹; ICCAA-AD = 0.97; P < 0.01), PDA-AD (6.95 ± 2.44 vs 6.95 ± 2.42 × 10⁻³ mm Hg⁻¹; ICCPDA-AD = 0.99; P < 0.01), DDA (10.54 ± 2.91 vs 10.55 ± 2.90 × 10⁻³ mm Hg⁻¹; ICCDDA-AD = 0.98, P < 0.01), and FMD (24.94 ± 12.55 vs 24.92 ± 12.38%; ICCFMD = 0.94, P < 0.01). Good agreement between repeated measurements was found for aortic PWV (confidence interval [CI], -0.55 to 0.50), AA-AD (CI, -0.11 to 0.12), PDA-AD (CI, -0.08 to 0.08), DDA-AD (CI, -0.23 to 0.21), and FMD (CI, -1.46 to 1.51).
CONCLUSION: Comprehensive assessment of aortic compliance and brachial endothelial function can be achieved in a single examination using 3.0-T high-resolution MRI with good reproducibility and within a reasonable amount of time.
Yan Shan; Jiang Lin; Pengju Xu; Jianjun Zhou; Mengsu Zeng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  36     ISSN:  1532-3145     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-18     Completed Date:  2012-09-25     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
From the Department of Diagnostic Radiology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
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MeSH Terms
Aorta / physiology*
Blood Flow Velocity / physiology
Brachial Artery / physiology*
Endothelium, Vascular / physiology*
Feasibility Studies
Magnetic Resonance Imaging / methods*
Reproducibility of Results

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