Document Detail

Comprehension of prosody in Huntington's disease.
MedLine Citation:
PMID:  2144017     Owner:  NLM     Status:  MEDLINE    
Patients with Huntington's Disease (HD) who were without dementia were compared to unilateral stroke patients and controls as previously reported in 1983, to discover if they had a prosodic defect. Subjects were presented tape-recorded speech filtered sentences and asked to indicate the tone of voice as happy, sad or angry (affective prosody), or as a question, command or statement (propositional prosody). HD patients were impaired in comprehension of both types of prosody compared to controls but were not different from stroke patients. A second study compared early HD patients with at-risk siblings and spouse controls on comprehension of affective and propositional prosody, discrimination of both types of prosody, rhythm discrimination and tonal memory (Seashore tests). HD patients were impaired in both comprehension and discrimination of all types of prosody. HD patients were less accurate than at-risk patients on the tonal memory task but not on the rhythm discrimination task. These findings suggest compromise in ability to understand the more subtle prosodic aspects of communication which may contribute to social impairment of HD patients very early in the course of the disease.
L J Speedie; N Brake; S E Folstein; D Bowers; K M Heilman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  53     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-02     Completed Date:  1990-10-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  607-10     Citation Subset:  IM    
Department of Psychiatry and Behavioural Sciences, Johns Hopkins University, Baltimore School of Medicine, Maryland.
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MeSH Terms
Cerebral Infarction / psychology
Dominance, Cerebral
Huntington Disease / genetics,  psychology*
Risk Factors
Speech Perception*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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