Document Detail


Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish.
MedLine Citation:
PMID:  15221325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Intrauterine infection is frequently associated with pregnancy loss in pregnant women. DISCUSSION: This article reviews the role of Gram-negative bacterial infection in various complications related to early pregnancy and subsequent pregnancy loss. Here we discuss the pathways of ascending intrauterine infection, microbiology and the pathophysiology of such infections. The clinical impact, therapy, consequences, prevention and implications of Gram-negative bacterial infections in women during their reproductive life span is also discussed. This article also makes an attempt to discuss our studies and findings, related to the effect of the LPS component of the Gram-negative bacterial endotoxin on preimplantation stage embryonic development and implantation. This early phase of pregnancy remains mostly unnoticed by the mother as well as the health care provider, and therefore holds more threat to the life of the fetus and the mother. The molecular mechanisms of LPS-induced pregnancy losses through abnormal embryonic development, implantation failure, and preterm labor and birth with specific references to the role of proinflammatory cytokines like IL-1 and TNF are discussed. CONCLUSION: Once these inflammatory mediators have increased in the feto-maternal tissues, it may be too late or harmful to try and prevent the adverse outcomes of pregnancy.
Authors:
Kaushik Deb; Madan Mohan Chaturvedi; Yogesh Kumar Jaiswal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2004-06-18
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  270     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2005-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  133-46     Citation Subset:  IM    
Affiliation:
Molecular Biology and Reproductive Immunology Laboratory, School of Studies in Biochemistry, Jiwaji University, 474 011 (MP) Gwalior, India. kaushik.deb@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Female
Gram-Negative Bacteria*
Gram-Negative Bacterial Infections / microbiology*
Humans
Lipopolysaccharides / adverse effects*
Pregnancy
Pregnancy Complications, Infectious / microbiology*
Pregnancy Outcome
Vaginosis, Bacterial / microbiology*
Chemical
Reg. No./Substance:
0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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