Document Detail

Compound dual radiation action theory for 252Cf brachytherapy.
MedLine Citation:
PMID:  15353749     Owner:  NLM     Status:  MEDLINE    
The existing dosimetry protocol that uses the concept of RBE for 252Cf brachytherapy contains large uncertainties. A new formula has been developed to correlate the biological effect (i.e. cell survival fraction) resulting from a mixed n + gamma radiation field with two physical quantities and two biological quantities. The formula is based on a pathway model evolved from that of the compound-dual-radiation-action (CDRA) theory, previously proposed by Rossi and Zaider. The new model employs the recently published data on radiation-induced DNA lesions. The new formula is capable of predicting quantitatively the synergistic effect caused by the interactions between neutron events and gamma ray events, and it is intended to be included into a new dosimetry protocol for future 252Cf brachytherapy.
C K Wang; X Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation protection dosimetry     Volume:  110     ISSN:  0144-8420     ISO Abbreviation:  Radiat Prot Dosimetry     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-08     Completed Date:  2004-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109958     Medline TA:  Radiat Prot Dosimetry     Country:  England    
Other Details:
Languages:  eng     Pagination:  801-6     Citation Subset:  IM    
Nuclear & Radiological Engineering Program, Georgia Institute of Technology, Neely Research Center, 900 Atlantic Drive, Atlanta, GA 30332-0425, USA.
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MeSH Terms
Body Burden
Brachytherapy / adverse effects,  methods*
Californium / adverse effects,  therapeutic use*
Cell Survival / radiation effects
Computer Simulation
DNA / radiation effects*
DNA Damage
Dose-Response Relationship, Radiation
Gamma Rays / adverse effects,  therapeutic use*
Models, Biological*
Neutrons / adverse effects,  therapeutic use*
Radiation Protection / methods
Radiometry / methods*
Radiotherapy Dosage
Relative Biological Effectiveness
Risk Assessment / methods
Risk Factors
Reg. No./Substance:
7440-71-3/Californium; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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