Document Detail


Compound A concentration in the circle absorber system during low-flow sevoflurane anesthesia: comparison of Drägersorb Free, Amsorb, and Sodasorb II.
MedLine Citation:
PMID:  12657409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVE: To determine compound A concentrations in a low-flow circuit containing Drägersorb Free (Dräger, Lübeck, Germany), Amsorb (Armstrong, Coleraine, Northern Ireland), and Sodasorb II (W. R. Grace, Lexington, MA). DESIGN: Randomized study. SETTING: Hamamatsu University Hospital. PATIENTS: 24 ASA physical status I and II patients scheduled for general anesthesia greater than 3 hours' duration. INTERVENTIONS: Patients were allocated to three groups of eight patients each to receive either using either Drägersorb Free, Amsorb, or Sodasorb II. Immediately before anesthesia induction, 1 kg of fresh absorbent was placed in the anesthesia canister. Anesthesia was maintained with sevoflurane (end-tidal concentration 1% to 3%) in oxygen and nitrous oxide (FIO(2) > 0.3) at a total flow of 1 L/min. MEASUREMENTS: Inspiratory compound A concentration in the circuit was measured once every hour. MAIN RESULTS: Maximum compound A concentrations for Drägersorb Free, Amsorb, and Sodasorb II were 2.4 +/- 0.8 (mean +/- SD) ppm, 3.1 +/- 0.5 ppm, and 28.0 +/- 10.0 ppm (p < 0.01 vs. Drägersorb Free and Amsorb). Concentrations with Drägersorb Free and Amsorb remained at less than 4 ppm throughout the study. CONCLUSIONS: Because compound A concentrations in the circuit with Drägersorb Free and Amsorb were negligible, sevoflurane can be used at a fresh gas flow of 1 L/min with these two absorbents.
Authors:
Shunji Kobayashi; Hiromichi Bito; Yukako Obata; Takasumi Katoh; Shigehito Sato
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Evaluation Studies; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  15     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan. je2fbw@hama-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Absorption
Adult
Anesthesia, Inhalation / instrumentation*
Anesthetics, Inhalation*
Calcium Chloride / chemistry*
Calcium Hydroxide / chemistry*
Carbon Dioxide / analysis
Ethers / analysis*
Female
Humans
Hydrocarbons, Fluorinated / analysis*
Male
Methyl Ethers*
Middle Aged
Chemical
Reg. No./Substance:
0/Amsorb; 0/Anesthetics, Inhalation; 0/Ethers; 0/Hydrocarbons, Fluorinated; 0/Methyl Ethers; 10043-52-4/Calcium Chloride; 124-38-9/Carbon Dioxide; 1305-62-0/Calcium Hydroxide; 28523-86-6/sevoflurane; 58109-34-5/fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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