Document Detail

Compound and compositions as TGR5 agonists: WO2012082947.
MedLine Citation:
PMID:  23409864     Owner:  NLM     Status:  Publisher    
The patent application WO2012082947 claims novel compounds as agonists of a plasma membrane-bound bile acid receptor TGR5. By activating TGR5, the agonists improve glycemic control and enhance energy expenditure. The basic generic claim of the patent covers pyrazole derivatives, different permutations on the core pyrazole ring are covered in the subsidiary claims. The claimed compounds are human TGR5 agonists having potency in the nM range.
Saurin Raval
Related Documents :
24646284 - Glutamatergic pathways as a target for the treatment of dyskinesias in parkinson's dise...
23707254 - Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems.
24360974 - Immunolocalization of estrogen and androgen receptors in the caput epididymidis of the ...
23045604 - Extensive evolutionary and functional diversity among mammalian aim2-like receptors.
20730384 - Dysfunction of g protein-coupled receptor kinases in alzheimer's disease.
9862694 - Terminal deoxynucleotidyl transferase expression during neonatal life alters d(h) readi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-15
Journal Detail:
Title:  Expert opinion on therapeutic patents     Volume:  -     ISSN:  1744-7674     ISO Abbreviation:  Expert Opin Ther Pat     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516419     Medline TA:  Expert Opin Ther Pat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Zydus Research Centre , Sarkhej-Bavla N. H.8A, Moraiya, Ahmedabad 382210 , India +91 2717 665555 ;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function ...
Next Document:  Early Detection of Brucella Canis via Quantitative Polymerase Chain Reaction Analysis.