Document Detail

Compositional volumetry of non-calcified coronary plaques by multislice computed tomography: an ex vivo feasibility study.
MedLine Citation:
PMID:  20142176     Owner:  NLM     Status:  MEDLINE    
AIMS: Non-invasive quantitative compositional analysis of coronary plaque would be a major advantage to study coronary artery disease. This study explores the application to use the Hounsfield units (HU) distribution of coronary plaques imaged by multislice computed tomography-coronary angiography (MSCT-CA). METHODS AND RESULTS: A dedicated computer-assisted method was developed to measure the HU distribution within a coronary plaque by MSCT-CA. To test the feasibility of the method, an ex vivo left anterior descending (LAD) coronary specimen, excised during autopsy, was imaged both by non-enhanced and enhanced MSCT-CA. Quantitative histology was used as a reference. To test the feasibility of the new volumetric analytic method, the MSCT-CA data were compared with volumetric histopathology. The coronary specimen, with a heterogeneously distributed plaque composition without large areas of calcification, was histologically sampled at five different locations, 5 mm apart, where at each location 15 sections were taken at 100 microm intervals, resulting in 75 individual histology sections. Tri-chrome Masson staining was used for histology quantification of three plaque/tissue components: smooth muscle cells (SMC), collagen and calcium. MSCT plaque composition was defined as "lower-HU" or "higher-HU" plaque and "calcium" based on the HU distribution. Comparison of the MSCT defined tissue components against histology showed a good relationship without significant differences. CONCLUSIONS: This ex vivo study shows the feasibility of using the Hounsfield unit distribution to perform compositional coronary plaque volumetry by MSCT-CA. The results are encouraging.
Nico Bruining; Jos R T C Roelandt; Stefan Verheye; Michiel Knaapen; Yoshinobu Onuma; Evelyn Regar; Filippo Cademartiri; Sebastiaan de Winter; Glenn Van Langenhove; Patrick W Serruys; Ronald Hamers; Pim J de Feyter
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  5     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  558-64     Citation Subset:  IM    
Department of Cardiology, Erasmus MC, Thoraxcenter, Rotterdam, The Netherlands.
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MeSH Terms
Azo Compounds / diagnostic use
Calcium / analysis
Collagen / analysis
Contrast Media / diagnostic use
Coronary Angiography / methods*
Coronary Artery Disease / metabolism,  radiography*
Coronary Vessels / chemistry,  pathology*
Eosine Yellowish-(YS) / diagnostic use
Feasibility Studies
Methyl Green / diagnostic use
Myocytes, Smooth Muscle / radiography
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Staining and Labeling / methods
Tomography, Optical Coherence
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Azo Compounds; 0/Contrast Media; 0/trichrome stain; 17372-87-1/Eosine Yellowish-(YS); 7440-70-2/Calcium; 82-94-0/Methyl Green; 9007-34-5/Collagen

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