Document Detail


Composition and synthesis of three higher ganglioside homologs in bovine mammary tissue.
MedLine Citation:
PMID:  628316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three higher gangliosides were identified as constituents of bovine mammary gland. The structures of these three gangliosides were shown to be ceramide-glucose-galactose-(sialic acid)-N-acetylgalactosamine-galactose, ceramide-glucose-galactose-(sialic acid)2-N-acetylgalactosamine, and ceramide-glucose-galactose-(sialic acid)2-N-acetylgalactosamine-galactose. These gangliosides accounted for only a small fraction (less than 20%) of the lipid-bound sialic in mammary gland. White fatty acids with even carbon numbers from C14 to C26 were predominant in these gangliosides, they also contained C23 and C25 fatty acids. Mammary gland Golgi apparatus-rich fractions had all glycosyltransferases required for synthesis of these gangliosides starting with ceramide.
Authors:
A A Bushway; T W Keenan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lipids     Volume:  13     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Female
Gangliosides / analysis*,  biosynthesis
Mammary Glands, Animal / analysis*,  metabolism
Milk / analysis
Chemical
Reg. No./Substance:
0/Gangliosides

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