Document Detail

Composition and synthesis of fatty acids in atherosclerotic aortas of the pigeon.
MedLine Citation:
PMID:  5685266     Owner:  NLM     Status:  MEDLINE    
The composition, synthesis, and esterification of fatty acids were studied in aortas of White Carneau and Show Racer pigeons after perfusion of the aortas with a medium containing acetate-1-(14)C. For both breeds of pigeons the principal change in aortic fatty acids, in response to an atherogenic diet, was a marked increase in the percentage of oleic acid in the cholesteryl ester fraction. In atherosclerotic aortas incorporation of acetate-1-(14)C into the phospholipid and glyceride fractions increased 2-fold, while a much greater increase (up to 10-fold) was seen in incorporation into cholesteryl esters. In those birds receiving the atherogenic diet, palmitic acid accounted for approximately 50% of the fatty acid radioactivity, compared with approximately 25% from control aortas. Calculation of fatty acid synthesis showed the major newly synthesized fatty acids to be stearic acid in the phospholipid fraction; stearic, palmitic, and oleic acids in the glycerides; and oleic acid in the cholesteryl esters. The pattern of fatty acid synthesis was closely similar to the actual fatty acid composition of the aorta. In atherosclerotic aortas an increased synthesis of all fatty acids was seen, but the greatest increase was seen in the synthesis of oleic acid and its esterification to cholesterol.
R W St Clair; H B Lofland; T B Clarkson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  9     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1968 Nov 
Date Detail:
Created Date:  1968-12-09     Completed Date:  1968-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  739-47     Citation Subset:  IM    
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MeSH Terms
Acetates / metabolism
Aorta / metabolism*
Aortic Diseases / chemically induced,  metabolism*,  pathology
Arteriosclerosis / chemically induced,  metabolism*,  pathology
Carbon Isotopes
Cholesterol / metabolism
Chromatography, Gas
Fatty Acids / biosynthesis,  metabolism*
Glycerides / biosynthesis
Oleic Acids / biosynthesis
Phospholipids / biosynthesis
Species Specificity
Reg. No./Substance:
0/Acetates; 0/Carbon Isotopes; 0/Fatty Acids; 0/Glycerides; 0/Oleic Acids; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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