Document Detail


Composition and roles of intestinal microbiota in children.
MedLine Citation:
PMID:  22348506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To provide an update of the advantages of new-generation molecular diagnostics to study the diversity of intestinal microflora and to evaluate its alteration in human diseases.
METHODS: We review recent advances in understanding the complex ecosystem of gut microbiota based on a dynamic and mutual interaction with the host.
RESULTS: In vaginal delivery, the contact with the mother's vaginal and intestinal flora is an important source of Lactobacillus, Prevotella and other Bifidobacterium. On the opposite, in cesarean delivery, direct contact of the mouth of the newborn with vaginal and intestinal microbiota is replaced by exogenous non-maternally derived bacteria colonizing the infants' intestine producing a less diverse flora. The original microbiome settings evolve during the growth converging to three main clusters defined "enterotypes" in the adult age.
CONCLUSIONS: The key role in human health could depend on the balance between beneficial and harmful microbial species populating the gut, therefore the intestinal microflora can been considered as a potential biomarker and/or therapeutic target in intestinal and extra-intestinal diseases.
Authors:
Alfredo Guarino; Anna Wudy; Francesca Basile; Eliana Ruberto; Vittoria Buccigrossi
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Publication Detail:
Type:  Journal Article; Retracted Publication; Review     Date:  2012-03-05
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25 Suppl 1     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-07-25     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Humans
Infant, Newborn*
Intestinal Diseases / microbiology
Intestines / microbiology*
Metagenome
Comments/Corrections
Retraction In:
Di Renzo GC, Maulik D, Treadway A. J Matern Fetal Neonatal Med. 2014 Jun;27(9):973   [PMID:  24766038 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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