Document Detail


Composition and roles of intestinal microbiota in children.
MedLine Citation:
PMID:  22348506     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Gut microbiota is a complex ecosystem based on a dynamic and mutual interaction with the host. In order to study the diversity of intestinal microflora, three approaches are most commonly used including gene targeting polymerase chain reaction (PCR), molecular fingerprinting techniques such as DGGE (denaturing gradient gel electrophoresis) and oligonucleotide probe-based hybridization techniques such as FISH (fluorescent in situ hybridization). In vaginal delivery, the contact with the mother's vaginal and intestinal flora is an important source of Lactobacillus, Prevotella and other Bifidobacterium. On the opposite, in cesarean delivery, direct contact of the mouth of the newborn with vaginal and intestinal microbiota is replaced by exogenous non-maternally derived bacteria colonizing the infants' intestine producing a less diverse flora. The original microbiome settings evolve during the growth converging to three main clusters defined "enterotypes" in the adult age. The key role in human health could depend on the balance between beneficial and harmful microbial species populating the gut, therefore the intestinal microflora can been considered as a potential biomarker and/or therapeutic target in intestinal and extra-intestinal diseases.
Authors:
Alfredo Guarino; Anna Wudy; Francesca Basile; Eliana Ruberto; Vittoria Buccigrossi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-21
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Paediatrics, University of Naples "Federico II, Via S. Pansini 5, 80131 Naples, Italy.
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