| Composition and permeability of syncytiotrophoblast plasma membranes in pregnancies complicated by intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 10446293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine placental membrane permeabilities to water, urea and mannitol in intrauterine growth restriction (IUGR) and compare them to normal gestational age matched controls. Further, we wished to investigate whether potential changes in permeability were related to changes in membrane fluidity, cholesterol or phospholipid fatty acid content of the membranes. Syncytiotrophoblast microvillous (MVM) and basal membranes (BM) were isolated from normal and IUGR placentas at term. Passive permeability to water, urea, and mannitol showed no significant alterations in IUGR compared to controls. Cholesterol content in BM, but not in MVM, was lower in placentas from pregnancies complicated by IUGR. However, membrane fluidity did not change in these pregnancies. The phospholipid fatty acid composition of the plasma membranes isolated from all placentas showed a predominance of unsaturated fatty acid species in the BM and saturated species in the MVM. In the MVM from IUGR, mead acid (20:3), behenic acid (22:0) and nervonic acid (24:1) constituted higher percentages of the total when compared to normally grown controls. In the BM from IUGR, mead acid (20:3) was increased relative to the total phospholipid fatty acid content. In conclusion, the syncytiotrophoblast membranes exhibit only minor changes in passive permeability and composition when the pregnancy is complicated by IUGR. |
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Authors:
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T L Powell; T Jansson; N P Illsley; M Wennergren; M Korotkova; B Strandvik |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1420 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-28 Completed Date: 1999-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 86-94 Citation Subset: IM |
Affiliation:
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Perinatal Center, Department of Physiology and Pharmacology, Göteborg University, Box 432, S-405 30, Göteborg, Sweden. theresa-powell@fysiologi.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Cell Membrane / chemistry, metabolism* Cell Membrane Permeability Cholesterol / metabolism Fatty Acids / analysis Female Fetal Growth Retardation / metabolism* Humans Mannitol / metabolism Membrane Fluidity Membrane Lipids / metabolism Phospholipids / chemistry, metabolism Pregnancy Pregnancy Complications / metabolism* Trophoblasts / chemistry, metabolism* Urea / metabolism Water / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD 26392/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Membrane Lipids; 0/Phospholipids; 57-13-6/Urea; 57-88-5/Cholesterol; 69-65-8/Mannitol; 7732-18-5/Water |
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