Document Detail

Composition and metabolism of phospholipids of human leukocytes.
MedLine Citation:
PMID:  7139846     Owner:  NLM     Status:  MEDLINE    
Human mononuclear (MN) and polymorphonuclear (PMN) leukocytes were analyzed for their phospholipid, triglyceride, cholesterol and fatty acid content. The phospholipid/cholesterol ratio was 1.24 for both cells. MN cells contain more phosphatidylcholine (PC), but less phosphatidylserine (PS), Phosphatidylethanolamine (PE) and sphingomyelin (SPH) than PMN cells when expressed as percent of total phospholipid. When expressed on the basis of lipid content per cell, MN cells contain less PS, PE and SPH but more triglyceride than PMN cells. PMN cells incorporate palmitic, stearic, linoleic and linolenic acids into their phospholipids, triglycerides or cholesterol esters. The incorporation into triglycerides was highest for all fatty acids. Of the phospholipids, the incorporation was highest into PC. Labeled fatty acids also were found in proteins which had been delipidized by exhaustive extraction with organic solvents. These represent tightly or covalently bound fatty acids. The incorporation [3H] palmitic acid into this protein fraction is stimulated by insulin.
G V Marinetti; K Cattieu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  31     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  169-77     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / biosynthesis
Cholesterol / blood
Fatty Acids / blood
Leukocytes / metabolism*
Lipids / blood
Lymphocytes / metabolism
Monocytes / metabolism
Neutrophils / metabolism
Phospholipids / biosynthesis,  blood*
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Blood Proteins; 0/Fatty Acids; 0/Lipids; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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