Document Detail


Composition of human pulmonary surfactant varies with exercise and level of fitness.
MedLine Citation:
PMID:  8004321     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have tested the hypothesis that the composition of alveolar surfactant varies with pattern of breathing and level of fitness. We examined three major components of surfactant, surfactant protein A (SP-A), disaturated phospholipids (DSP), and cholesterol (CHOL) in bronchoalveolar lavage (BAL) fluid from 12 healthy men before and after exercise. Fitness was assessed as work load/heart rate ([kpm.min-1]/[HR.HRmax-1]) achieved during cycling for 30 min at 90% theoretical maximal heart rate. Using a bronchoscope, four 20-ml vols of 0.15 M NaCl at 37 degrees C were instilled and then recovered from first a right upper and then a right lower lobe segmental bronchus. As we found no differences in the BAL from upper and lower lobes, the fluid was combined. We found a direct relationship between CHOL and DSP (rs = 0.84, p < 0.001), SP-A and CHOL (rs = 0.40, p < 0.025), and between SP-A and DSP (rs = 0.44, p < 0.025). The change in the ratios CHOL/DSP, SP-A/CHOL, and SP-A/DSP immediately after exercise was correlated with fitness (rs = -0.56, p < 0.025; rs = 0.75, p < 0.005; rs = 0.62, p < 0.025, respectively). We conclude that the composition of surfactant can change rapidly with exercise in a manner related to fitness, and we suggest that this is consistent with the existence of at least two pools of tissue surfactant of different composition supplying the alveolar compartment.
Authors:
I R Doyle; M E Jones; H A Barr; S Orgeig; A J Crockett; C F McDonald; T E Nicholas
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  149     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-15     Completed Date:  1994-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1619-27     Citation Subset:  AIM; IM    
Affiliation:
Department of Human Physiology, School of Medicine, Flinders Medical Centre, Adelaide, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibody Specificity*
Bronchoalveolar Lavage Fluid / chemistry*,  cytology
Cell Count
Cholesterol / analysis*,  immunology
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Exercise*
Exercise Test
Heart Rate
Humans
Male
Middle Aged
Phosphatidylcholines / analysis*,  immunology
Physical Fitness*
Proteolipids / analysis*,  immunology
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants / analysis*,  immunology
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Proteolipids; 0/Pulmonary Surfactant-Associated Protein A; 0/Pulmonary Surfactant-Associated Proteins; 0/Pulmonary Surfactants; 0/lecithins, disaturated; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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