| Composition of fatty oils from Semen Ziziphi Spinosae and its cardiotonic effect on isolated toad hearts. | |
| | |
MedLine Citation:
|
PMID: 21707231 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this study, the composition of fatty oil from Semen Ziziphi Spinosae and its cardiotonic activity on the heart isolated from a toad were studied. Oil-in-water (O/W) emulsions of fatty oil were prepared by the perfusion method. The fatty oil had a positive inotropic effect on isolated rat hearts at a concentration between 5 × 10(-3) and 2 × 10(-2) mL/10 mL, and the effect was in positive correlation with the concentration of calcium ions. In addition, this effect was inhibited by 2 mg/mL nifedipine, suggesting that the cardiotonic mechanism could be responsible for accelerating the inflow of calcium ions. Gas chromatography-mass spectrometry analysis showed that the main constituents of the fatty oil were 9-octadecenoic acid (43.32%), 9,12-octadecadienoic acid (42.57%), hexadecanoic acid (4.76%), 9-eicosenoic acid (2.95%), stearic acid (2.41%) and arachidic acid (0.81%). This preliminary study revealed that the fatty oil of Semen Ziziphi Spinosae exhibited remarkable cardiotonic activity in the tested models, and it is necessary to further reveal the effective substances of the fatty oil. |
| | |
Authors:
|
Junbo Xie; Yanqing Zhang; Lijuan Wang; Wuqin Qi; Mingchun Zhang |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-27 |
Journal Detail:
|
Title: Natural product research Volume: - ISSN: 1478-6427 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
a Department of Pharmaceutical Engineering , Tianjin University of Commerce , Tianjin 300134 , China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The use of spray-drying to enhance celecoxib solubility.
Next Document: Long-term time course of affective lability after subthalamic deep brain stimulation electrode impla...