Document Detail

Composition of ascitic fluid in liver cirrhosis: bile acid and lipid content.
MedLine Citation:
PMID:  8243523     Owner:  NLM     Status:  MEDLINE    
The concentrations of lipids, bile acids and proteins were evaluated in the ascitic fluid and plasma of 23 cirrhotics. Ascitic fluid density was highly correlated with its protein content, represented mostly by low molecular weight proteins. The ratio of plasma to ascitic fluid concentrations of nine examined proteins increased with molecular weight, indicating a selective ultrafiltration of the peritoneal transudate. Low density lipoproteins in ascitic fluid had modified electrophoretic mobility. Total cholesterol had a higher plasma to ascitic fluid ratio than high density lipoprotein cholesterol, whereas bile acids and proteins had similar plasma to ascitic fluid ratios. Indeed, bile acids strongly bind to circulating albumin: consequently ascitic fluid contains more cholic acid (less hydrophobic) than other bile acids. Analysis of both plasma and ascitic fluid composition in cirrhotics provides useful information on processes regulating passage of blood components into the peritoneal cavity.
G Salvioli; C Tata; R Panini; M Pellati; R Lugli; E Gaetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  23     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-04     Completed Date:  1994-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  534-9     Citation Subset:  IM    
Cattedra di Gerontologia e Geriatria, Università di Modena, Italy.
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MeSH Terms
Ascitic Fluid / chemistry*
Bile Acids and Salts / analysis*,  blood
Lipids / analysis*,  blood
Liver Cirrhosis* / blood
Middle Aged
Proteins / analysis*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Lipids; 0/Proteins

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