Document Detail

Composition of EEG oscillations and their temporal characteristics: methadone treatment.
MedLine Citation:
PMID:  17320229     Owner:  NLM     Status:  MEDLINE    
In this study, we examine the composition of electroencephalographic (EEG) oscillations within a broad frequency band (0.5-30 Hz) for opioid abuse (22 patients), during withdrawal (13 patients), and after 6 months of methadone treatment (6 patients) and in 14 healthy subjects during a resting condition (closed eyes). The exact compositions of EEG oscillations and their temporal behaviour were assessed using the probability-classification analysis of short-term EEG spectral patterns. The study reveals the dynamics of particular EEG oscillations throughout the conditions of opioid dependency, withdrawal and methadone-based treatment. It was shown that methadone maintenance treatment normalized considerably the composition of EEG oscillations and their percentage ratio and restored the temporal structure of patients' EEG comparable with healthy subjects. The importance of the methadone's ability to restore a normal temporal structure of the brain's activity is discussed.
Alexander A Fingelkurts; Seppo Kähkönen; Andrew A Fingelkurts; Reetta Kivisaari; Sergei Borisov; Varpu Puuskari; Olga Jokela; Taina Autti
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-13
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  64     ISSN:  0167-8760     ISO Abbreviation:  Int J Psychophysiol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-07-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  130-40     Citation Subset:  IM    
BM-SCIENCE - Brain and Mind Technologies Research Centre, Espoo, Finland.
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MeSH Terms
Brain / drug effects*,  physiology,  physiopathology
Cortical Synchronization / drug effects
Electroencephalography / drug effects*
Methadone / pharmacology*,  therapeutic use
Narcotics / pharmacology*,  therapeutic use
Opioid-Related Disorders / drug therapy,  physiopathology*
Reference Values
Substance Withdrawal Syndrome / drug therapy,  physiopathology*
Time Factors
Reg. No./Substance:
0/Narcotics; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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