| Composite ganglioneuroma-paraganglioma of the filum terminale. | |
| | |
MedLine Citation:
|
PMID: 20515359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Extraadrenal paragangliomas are most commonly found in the carotid body and are also found with lower frequency in the CNS. These lesions are derived from the sympathoadrenal lineage of neural crest cells. Here, the authors report a rare case of a composite paraganglioma with ganglioneuromatous components found at the filum terminale in a patient who presented with a brief history of low-back pain and paresthesias in the inguinal region. Immunohistochemical analysis of the resected lesion revealed admixed elements of neuroendocrine and neuroblastoma lineages, indicating the presence of divergent differentiation of sympathoadrenal progenitor cells. This case represents a unique opportunity to understand the cell fate of sympathoadrenal progenitor cells. Here, the authors propose that paragangliomas at the filum terminale can revert to a neural crest cell precursor fate, giving rise to divergent neoplastic populations. |
| | |
Authors:
|
Ganesh M Shankar; Li Chen; Albert H Kim; Gina L Ross; Rebecca D Folkerth; Robert M Friedlander |
Related Documents
:
|
1151269 - Differentiation in vitro of sympathetic cells from chick embryo sensory ganglia. 15804839 - Photoreceptors derived from adult iris tissue: prospects for retinal transplantation. 11814109 - Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degenera... 10080299 - Isotretinoin alters morphology, polarity, and motility of neural crest cells in culture. 20211169 - Cellular origin and developmental mechanisms during the formation of skin melanocytes. 8162849 - Segment and cell type lineage restrictions during pharyngeal arch development in the ze... 22554109 - Glutathione serves an extracellular defence function to decrease arsenite accumulation ... 12530009 - Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lin... 16325369 - The interaction between acanthamoeba polyphaga and human osteoblastic cells in vitro. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of neurosurgery. Spine Volume: 12 ISSN: 1547-5646 ISO Abbreviation: J Neurosurg Spine Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-02 Completed Date: 2010-07-07 Revised Date: 2010-07-12 |
Medline Journal Info:
|
Nlm Unique ID: 101223545 Medline TA: J Neurosurg Spine Country: United States |
Other Details:
|
Languages: eng Pagination: 709-13 Citation Subset: IM |
Affiliation:
|
Departments of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cauda Equina* Ganglioneuroma / pathology*, surgery Humans Magnetic Resonance Imaging Male Middle Aged Paraganglioma / pathology*, surgery Peripheral Nervous System Neoplasms / pathology*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biomechanical comparison of single-level posterior versus transforaminal lumbar interbody fusions wi...
Next Document: Cognitive reserve in paediatric traumatic brain injury: relationship with neuropsychological outcome...