Document Detail

Composite ganglioneuroma-paraganglioma of the filum terminale.
MedLine Citation:
PMID:  20515359     Owner:  NLM     Status:  MEDLINE    
Extraadrenal paragangliomas are most commonly found in the carotid body and are also found with lower frequency in the CNS. These lesions are derived from the sympathoadrenal lineage of neural crest cells. Here, the authors report a rare case of a composite paraganglioma with ganglioneuromatous components found at the filum terminale in a patient who presented with a brief history of low-back pain and paresthesias in the inguinal region. Immunohistochemical analysis of the resected lesion revealed admixed elements of neuroendocrine and neuroblastoma lineages, indicating the presence of divergent differentiation of sympathoadrenal progenitor cells. This case represents a unique opportunity to understand the cell fate of sympathoadrenal progenitor cells. Here, the authors propose that paragangliomas at the filum terminale can revert to a neural crest cell precursor fate, giving rise to divergent neoplastic populations.
Ganesh M Shankar; Li Chen; Albert H Kim; Gina L Ross; Rebecca D Folkerth; Robert M Friedlander
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Spine     Volume:  12     ISSN:  1547-5646     ISO Abbreviation:  J Neurosurg Spine     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-07-07     Revised Date:  2010-07-12    
Medline Journal Info:
Nlm Unique ID:  101223545     Medline TA:  J Neurosurg Spine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  709-13     Citation Subset:  IM    
Departments of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Cauda Equina*
Ganglioneuroma / pathology*,  surgery
Magnetic Resonance Imaging
Middle Aged
Paraganglioma / pathology*,  surgery
Peripheral Nervous System Neoplasms / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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