Document Detail


Composite cardiac binding in experimental heart failure.
MedLine Citation:
PMID:  10735676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Composite cardiac binding consists of wrapping the heart with a synthetic membrane and a pericardial interposition. The goal of the present study was to apply composite cardiac binding to a canine model of heart failure. METHODS: Twenty dogs were randomized to 2 groups: untreated heart failure (group 1, n = 13) and heart failure pretreated by composite cardiac binding (group 2, n = 7). They received a total dose of 1 mg x kg(-1) of intracoronary doxorubicin over 4 weeks. Hemodynamic data were obtained at weeks 0, 7, and 12. All animals were followed up with weekly echocardiography for 12 weeks. RESULTS: Survival in group 1 was 54% and in group 2 was 100% at week 12 (p = 0.0438). Left ventricular end-diastolic pressure increased by 153% in group 1 and by 59% in group 2 (p = 0.0395) at week 12. Ejection fraction decreased by 27% in group 1 and by 19% in group 2 (p = 0.4401) at week 12. CONCLUSIONS: Composite cardiac binding significantly prolongs survival and attenuates left ventricular dilatation and the increase in left ventricular end-diastolic pressure associated to chronic heart failure. Further evaluation in established heart failure is needed. Composite cardiac binding may be used for the prevention of recurrent dilatation following reduction ventriculoplasty.
Authors:
H R Shah; M Vaynblat; L Salciccioli; P Impellizzeri; J N Cunningham; M Chiavarelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  69     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-12     Completed Date:  2000-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery and Medicine, State University of New York Health Science Center, Brooklyn 11203, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathy, Dilated / physiopathology,  surgery*
Cardiomyoplasty / methods*
Disease Models, Animal
Dogs
Evaluation Studies as Topic
Hemodynamics
Male
Pericardium / transplantation*
Random Allocation
Stroke Volume
Transplantation, Autologous
Ventricular Function, Left
Comments/Corrections
Comment In:
Ann Thorac Surg. 2001 May;71(5):1754-5   [PMID:  11383857 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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