Document Detail

Composite cardiac binding in experimental heart failure.
MedLine Citation:
PMID:  10735676     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Composite cardiac binding consists of wrapping the heart with a synthetic membrane and a pericardial interposition. The goal of the present study was to apply composite cardiac binding to a canine model of heart failure. METHODS: Twenty dogs were randomized to 2 groups: untreated heart failure (group 1, n = 13) and heart failure pretreated by composite cardiac binding (group 2, n = 7). They received a total dose of 1 mg x kg(-1) of intracoronary doxorubicin over 4 weeks. Hemodynamic data were obtained at weeks 0, 7, and 12. All animals were followed up with weekly echocardiography for 12 weeks. RESULTS: Survival in group 1 was 54% and in group 2 was 100% at week 12 (p = 0.0438). Left ventricular end-diastolic pressure increased by 153% in group 1 and by 59% in group 2 (p = 0.0395) at week 12. Ejection fraction decreased by 27% in group 1 and by 19% in group 2 (p = 0.4401) at week 12. CONCLUSIONS: Composite cardiac binding significantly prolongs survival and attenuates left ventricular dilatation and the increase in left ventricular end-diastolic pressure associated to chronic heart failure. Further evaluation in established heart failure is needed. Composite cardiac binding may be used for the prevention of recurrent dilatation following reduction ventriculoplasty.
H R Shah; M Vaynblat; L Salciccioli; P Impellizzeri; J N Cunningham; M Chiavarelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  69     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-12     Completed Date:  2000-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  AIM; IM    
Department of Surgery and Medicine, State University of New York Health Science Center, Brooklyn 11203, USA.
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MeSH Terms
Cardiomyopathy, Dilated / physiopathology,  surgery*
Cardiomyoplasty / methods*
Disease Models, Animal
Evaluation Studies as Topic
Pericardium / transplantation*
Random Allocation
Stroke Volume
Transplantation, Autologous
Ventricular Function, Left
Comment In:
Ann Thorac Surg. 2001 May;71(5):1754-5   [PMID:  11383857 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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