| Composite Peripheral T-cell Lymphoma, Not Otherwise Specified and B-cell Small Lymphocytic Lymphoma Presenting With Hemophagocytic Lymphohistiocytosis. | |
| | |
MedLine Citation:
|
PMID: 23129836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We report a case of a 68-year-old female patient who developed hemophagocytic lymphohistiocytosis (HLH) secondary to peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS) that developed in the setting of treatment-resistant B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL). The patient's B-cell lymphoma had a good initial response to chemotherapy for 4 years, after which it became less responsive and was thought to have undergone transition to a higher-grade lymphoma. Different regimens of chemoradiotherapy were then tried with modest response until the patient presented 3 years later with signs and symptoms of HLH. The patient died 1 month later, and an autopsy was performed. Significant para-aortic lymphadenopathy and splenomegaly were found. Microscopic, immunohistochemical and molecular evaluations confirmed the presence of composite B-cell and T-cell lymphoma in the para-aortic enlarged lymph nodes. Bone marrow examination showed hemophagocytosis, and the liver demonstrated infiltration by activated macrophages with hepatocellular necrosis. This report highlights the importance of searching for a possible underlying T-cell lymphoma in light of HLH. Different theories have been proposed to explain the rare occurrence of concurrent B- and T-cell lymphomas, but the development of HLH in this patient highlights the importance of immune dysregulation as a proposed mechanism to explain some cases of composite lymphomas. A review of the literature and discussion of the relative merits of these hypotheses are presented in the context of this case. |
| | |
Authors:
|
Ahmed Alomari; Pei Hui; Mina Xu |
Related Documents
:
|
23577036 - Therapeutic potential of mesenchymal stem cells in regenerative medicine. 16243526 - Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, ... 23254356 - Tc9 cells, a new subset of cd8(+) t cells, support th2-mediated airway inflammation. 23558576 - Immunohistochemical stains for cd3 and cd8 do not improve detection of gluten-sensitive... 303966 - Increase in autologous erythrocyte binding by t cells with ageing in man. 800406 - The dissociation of adjuvant properties of mycobacterial components from mitogenicity, ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-4 |
Journal Detail:
|
Title: International journal of surgical pathology Volume: - ISSN: 1940-2465 ISO Abbreviation: Int. J. Surg. Pathol. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9314927 Medline TA: Int J Surg Pathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Life satisfaction and feeling in control: Indicators of successful aging predict mortality in old ag...
Next Document: Desmoplastic Medulloblastoma Arising From an Ovarian Teratoma: A Case Report and Review of the Liter...