| Composite MRI scores improve correlation with EDSS in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 20813778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples. OBJECTIVE: To explore the correlation of MRI-derived measures with EDSS through composite MRI scores. METHODS: Magnetic resonance images of 126 patients with relapsing-remitting MS were segmented into white and gray matter, cerebrospinal fluid, T2-hyperintense lesions, gadolinium contrast-enhancing lesions, T1-hypointense lesions ('black holes': BH). The volumes and average T2 values for each of these tissues and lesions were calculated and converted to a z-score (in units of standard deviation from the mean). These z-scores were combined to construct composite z-scores, and evaluated against individual z-scores for correlation with EDSS. RESULTS: Composite scores including relaxation times of different tissues and/or volumetric measures generally correlated more strongly with EDSS than individual measures. The maximum observed correlation of a composite with EDSS was r = 0.344 (p < 0.0001), which is an improvement over the highest-performing single MRI measure (BH; r = 0.298, p < 0.001). CONCLUSION: Z-transformation permits construction of composite scores including volumetric and T2-relaxation measures. Inclusion of multiple MRI measures in the composite can provide a broader characterization of the disease process, resulting in more robust correlations with EDSS. |
| | |
Authors:
|
A H Poonawalla; S Datta; V Juneja; F Nelson; J S Wolinsky; G Cutter; P A Narayana |
Related Documents
:
|
1764408 - Assessing the prevalence of cognitive impairment in multiple sclerosis: implications fo... 9647278 - Differential diagnosis of multiple sclerosis: contribution of magnetic resonance techni... 15760868 - Cortical lesions in multiple sclerosis: combined postmortem mr imaging and histopathology. 16775258 - Multiple sclerosis: the role of mr imaging. 11479008 - Age related signal decrease in functional magnetic resonance imaging during motor stimu... 22428948 - Optical coherence tomography in optic nerve head avulsion. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 16 ISSN: 1477-0970 ISO Abbreviation: Mult. Scler. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-03 Completed Date: 2010-12-29 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
|
Languages: eng Pagination: 1117-25 Citation Subset: IM |
Affiliation:
|
Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, Houston TX, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Contrast Media / diagnostic use Cross-Sectional Studies Disability Evaluation* Female Gadolinium / diagnostic use Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging* Male Middle Aged Multiple Sclerosis, Relapsing-Remitting / diagnosis*, pathology Predictive Value of Tests Severity of Illness Index Texas |
| Grant Support | |
ID/Acronym/Agency:
|
EB02095/EB/NIBIB NIH HHS; R01 EB002095-06A1/EB/NIBIB NIH HHS; R01 EB002095-09/EB/NIBIB NIH HHS; S10 RR019186-01/RR/NCRR NIH HHS; S10 RR19186/RR/NCRR NIH HHS; U01-NS045719/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 7440-54-2/Gadolinium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development and validation of a patient self-assessed questionnaire on satisfaction with communicati...
Next Document: Post-traumatic stress disorder, drug abuse and migraine: new findings from the National Comorbidity ...