Document Detail


Composite MRI scores improve correlation with EDSS in multiple sclerosis.
MedLine Citation:
PMID:  20813778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples.
OBJECTIVE: To explore the correlation of MRI-derived measures with EDSS through composite MRI scores.
METHODS: Magnetic resonance images of 126 patients with relapsing-remitting MS were segmented into white and gray matter, cerebrospinal fluid, T2-hyperintense lesions, gadolinium contrast-enhancing lesions, T1-hypointense lesions ('black holes': BH). The volumes and average T2 values for each of these tissues and lesions were calculated and converted to a z-score (in units of standard deviation from the mean). These z-scores were combined to construct composite z-scores, and evaluated against individual z-scores for correlation with EDSS.
RESULTS: Composite scores including relaxation times of different tissues and/or volumetric measures generally correlated more strongly with EDSS than individual measures. The maximum observed correlation of a composite with EDSS was r = 0.344 (p < 0.0001), which is an improvement over the highest-performing single MRI measure (BH; r = 0.298, p < 0.001).
CONCLUSION: Z-transformation permits construction of composite scores including volumetric and T2-relaxation measures. Inclusion of multiple MRI measures in the composite can provide a broader characterization of the disease process, resulting in more robust correlations with EDSS.
Authors:
A H Poonawalla; S Datta; V Juneja; F Nelson; J S Wolinsky; G Cutter; P A Narayana
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  16     ISSN:  1477-0970     ISO Abbreviation:  Mult. Scler.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-12-29     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  1117-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Contrast Media / diagnostic use
Cross-Sectional Studies
Disability Evaluation*
Female
Gadolinium / diagnostic use
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging*
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / diagnosis*,  pathology
Predictive Value of Tests
Severity of Illness Index
Texas
Grant Support
ID/Acronym/Agency:
EB02095/EB/NIBIB NIH HHS; R01 EB002095/EB/NIBIB NIH HHS; R01 EB002095-06A1/EB/NIBIB NIH HHS; S10 RR019186/RR/NCRR NIH HHS; S10 RR019186-01/RR/NCRR NIH HHS; S10 RR19186/RR/NCRR NIH HHS; U01-NS045719/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; AU0V1LM3JT/Gadolinium
Comments/Corrections

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