| Components from the steamed leaves of Acanthopanax koreanum and their effects on PPAR activity in HepG2 cells. | |
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MedLine Citation:
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PMID: 21941885 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Three ent-kaurane diterpenes (1-3), four lupane-triterpene glycosides (4-7), and an oleanane-triterpene glycoside (8) were isolated from the ethyl acetate and water extracts of the steamed leaves of Acanthopanax koreanum using a combination of various column chromatographies. The structures of the isolates were determined by 1H-, 13C-NMR spectroscopy and mass spectrometry. To investigate the biological effects of the eight compounds (1-8) on peroxisome proliferator-activated receptor gamma (PPARgamma), luciferase reporter assays were used. Among the tested compounds, ent-kaur-16-en-19-oic acid (1), 16alpha-hydroxy-ent-kauran-19-oic acid (2), and 17-hydroxy-ent-kaur-15-en-19-oic acid (3) showed considerable effects on PPARgamma activity, compared with the positive control, troglitazone. To evaluate specificity and sensitivity of the active compounds (1-3) in the regulation of transactivation of PPARs, Gal4-PPARs-LBD luciferase reporter assays were examined. In this study, the three ent-kaurane diterpenes (1-3) were found to up-regulate PPARbeta/delta and PPARgamma activities, whereas they did not activate PPARalpha activity. |
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Authors:
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Jeong Ah Kim; Seek Bean Song; Seo Young Yang; Young Ho Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product communications Volume: 6 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1233-6 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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