| Components of the blood acid-base disturbance that accompanies urethane anaesthesia in rats during normothermia and hypothermia. | |
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MedLine Citation:
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PMID: 9248667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. We have studied the components of the metabolic acidosis that accompanies urethane anaesthesia in rats, both with and without the hypothermia that results from this anaesthesia. 2. Acid-base disturbances were analysed with an approach based on Stewart's analysis of acid-base chemistry. 3. The pH fall in the blood of normothermic anaesthetized rats (body temperature Tb) = 37 degrees C) was related to increases in plasma anions (lactate and [Cl-]), which decreased the strong ion difference ([SID]), as well as to increase the weak acid buffers due to increases in albumin. 4. A stronger metabolic acidosis was found in the blood of rats with hypothermia induced by urethane (Tb = 32 degrees C). Although plasma lactate was unchanged in hypothermic rats, [SID] decreased due to alterations in the plasma ionic balance. The metabolic acidosis found in hypothermia was also associated with increased weak acid buffers due to increases in albumin and inorganic phosphate. Further to hyperphosphataemia, signs of acute renal disfunction, such as increases in plasma [Mg2+] and blood urea nitrogen were found. Plasma retention of endogenous acids together with the retention of acid end-products of the metabolism of urethane because of acute renal failure may have contributed to strengthening the fall in pH and [HCO3-] found in urethane-induced hypothermic rats. |
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Authors:
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V Alfaro; L Palacios |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 24 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-21 Completed Date: 1997-10-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 498-502 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Barcelona, Spain. valfaro@porthos.bio.ub.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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blood*,
chemically induced Anesthesia, General / adverse effects* Anesthetics, General / adverse effects Animals Bicarbonates / blood Carbon Dioxide / blood Chlorides / blood Hydrogen-Ion Concentration Hypothermia / blood*, chemically induced Lactic Acid / blood Male Rats Rats, Sprague-Dawley Serum Albumin / chemistry Urethane / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, General; 0/Bicarbonates; 0/Chlorides; 0/Serum Albumin; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 51-79-6/Urethane |
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