Document Detail

Component-resolved in vitro diagnosis of hazelnut allergy in Europe.
MedLine Citation:
PMID:  19344939     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Food allergy to hazelnut occurs both with and without concomitant pollen allergy. OBJECTIVE: We sought to evaluate a panel of hazelnut allergens for diagnosis of hazelnut allergy in Spain, Switzerland, and Denmark. METHODS: Fifty-two patients with a positive double-blind, placebo-controlled food challenge result with hazelnuts; 5 patients with a history of anaphylaxis; 62 patients with pollen allergy but hazelnut tolerance; and 63 nonatopic control subjects were included. Serum IgE levels to hazelnut extract, recombinant hazelnut allergens (rCor a 1.04, rCor a 2, rCor a 8, rCor a 11), and native allergens (nCor a 9, nCor a Bd8K, nCor a Bd11K) were analyzed by means of ImmunoCAP. RESULTS: Among patients with hazelnut allergy, 91% (Switzerland/Spain, 100%; Denmark, 75%) had IgE to hazelnut extract, 75% to rCor a 1.04, 42% to rCor a 2, 28% to rCor a 8, and 2% to rCor a 11. The highest rate of sensitization to Cor a 1.04 was found in the northern regions (Switzerland/Denmark, 100%; Spain, 18%), whereas IgE to the lipid transfer protein rCor a 8 prevailed in Spain (Spain, 71%; Switzerland, 15%; Denmark, 5%). IgE to profilin rCor a 2 was equally distributed (40% to 45%). Among control subjects with pollen allergy, 61% had IgE to hazelnut extract, 69% to rCor a 1.04, 34% to rCor a 2, 10% to rCor a 8, and 6% to rCor a 11. CONCLUSION: Component-resolved in vitro analyses revealed substantial differences in IgE profiles of hazelnut allergic and hazelnut tolerant patients across Europe.
Kirsten Skamstrup Hansen; Barbara K Ballmer-Weber; Joaquin Sastre; Jonas Lidholm; Kerstin Andersson; Hubert Oberhofer; Magdalena Lluch-Bernal; Jonas Ostling; Lars Mattsson; Frauke Schocker; Stefan Vieths; Lars K Poulsen
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-04-02
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  123     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1134-41, 1141.e1-3     Citation Subset:  AIM; IM    
Allergy Clinic, National University Hospital, Copenhagen, Denmark.
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MeSH Terms
Allergens / diagnostic use*,  genetics,  immunology
Anaphylaxis / diagnosis,  immunology
Corylus / immunology*
Immunoglobulin E / blood*
Middle Aged
Nut Hypersensitivity / diagnosis*,  immunology
Recombinant Proteins / diagnostic use,  genetics,  immunology
Rhinitis, Allergic, Seasonal / diagnosis,  immunology
Sensitivity and Specificity
Young Adult
Reg. No./Substance:
0/Allergens; 0/Recombinant Proteins; 37341-29-0/Immunoglobulin E

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