| Component-resolved in vitro diagnosis of hazelnut allergy in Europe. | |
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MedLine Citation:
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PMID: 19344939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Food allergy to hazelnut occurs both with and without concomitant pollen allergy. OBJECTIVE: We sought to evaluate a panel of hazelnut allergens for diagnosis of hazelnut allergy in Spain, Switzerland, and Denmark. METHODS: Fifty-two patients with a positive double-blind, placebo-controlled food challenge result with hazelnuts; 5 patients with a history of anaphylaxis; 62 patients with pollen allergy but hazelnut tolerance; and 63 nonatopic control subjects were included. Serum IgE levels to hazelnut extract, recombinant hazelnut allergens (rCor a 1.04, rCor a 2, rCor a 8, rCor a 11), and native allergens (nCor a 9, nCor a Bd8K, nCor a Bd11K) were analyzed by means of ImmunoCAP. RESULTS: Among patients with hazelnut allergy, 91% (Switzerland/Spain, 100%; Denmark, 75%) had IgE to hazelnut extract, 75% to rCor a 1.04, 42% to rCor a 2, 28% to rCor a 8, and 2% to rCor a 11. The highest rate of sensitization to Cor a 1.04 was found in the northern regions (Switzerland/Denmark, 100%; Spain, 18%), whereas IgE to the lipid transfer protein rCor a 8 prevailed in Spain (Spain, 71%; Switzerland, 15%; Denmark, 5%). IgE to profilin rCor a 2 was equally distributed (40% to 45%). Among control subjects with pollen allergy, 61% had IgE to hazelnut extract, 69% to rCor a 1.04, 34% to rCor a 2, 10% to rCor a 8, and 6% to rCor a 11. CONCLUSION: Component-resolved in vitro analyses revealed substantial differences in IgE profiles of hazelnut allergic and hazelnut tolerant patients across Europe. |
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Authors:
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Kirsten Skamstrup Hansen; Barbara K Ballmer-Weber; Joaquin Sastre; Jonas Lidholm; Kerstin Andersson; Hubert Oberhofer; Magdalena Lluch-Bernal; Jonas Ostling; Lars Mattsson; Frauke Schocker; Stefan Vieths; Lars K Poulsen |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-04-02 |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 123 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1134-41, 1141.e1-3 Citation Subset: AIM; IM |
Affiliation:
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Allergy Clinic, National University Hospital, Copenhagen, Denmark. ksh@dadlnet.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / diagnostic use*, genetics, immunology Anaphylaxis / diagnosis, immunology Corylus / immunology* Denmark Female Humans Immunoglobulin E / blood* Male Middle Aged Nut Hypersensitivity / diagnosis*, immunology Recombinant Proteins / diagnostic use, genetics, immunology Rhinitis, Allergic, Seasonal / diagnosis, immunology Sensitivity and Specificity Spain Switzerland Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Recombinant Proteins; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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