Document Detail


Component pathogen inactivation: a critical review.
MedLine Citation:
PMID:  23134556     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Objectives  Pathogen inactivation (PI)-treated plasma and platelets are increasingly becoming the products of choice, where licensed. This review summarizes the clinical evidence available for licensed component PI technologies and red cell PI under development. Materials and Methods  Available literature on licensed technologies was reviewed. Results  For the plasma and platelets technologies available, evidence for the inactivation of most pathogens is good, except for certain nonenveloped viruses. Clinical trials and haemovigilance programmes suggest the observed loss of potency is of little clinical significance, with some technology-specific exceptions. Concerns over adverse toxicological effects or neoantigen formation have not been confirmed for currently licensed products. Conclusion  While platelet PI has been adopted to reduce bacterial contamination, the ability of PI methods to replace testing for emerging bloodborne infections, or as a substitute for selective pathogen testing, gamma-irradiation or even leucodepletion, make adoption of PI for components increasingly attractive.
Authors:
C V Prowse
Related Documents :
24297316 - Generation of megakaryocytes and platelets from human pluripotent stem cells.
23086 - Influence of inorganic phosphate and organic buffers on cephalosporin production by str...
11683356 - Effects of acetate and butyrate during glycerol fermentation by clostridium butyricum.
15538656 - Kinetic resolution of ketoprofen ester catalyzed by lipase from a mutant of cbs 5791.
7749846 - Aurintricarboxylic acid prevents acute rethrombosis in a canine model of arterial throm...
1321466 - Inhibitory effect of 17 beta -estradiol on prostaglandin e2-induced phosphoinositide hy...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Vox sanguinis     Volume:  -     ISSN:  1423-0410     ISO Abbreviation:  Vox Sang.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion.
Affiliation:
Edinburgh University, Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enhancement of meristem formation by bouquet-1, a mis-sense allele of the VERNALIZATION INDEPENDENCE...
Next Document:  ACTH-secreting Crooke cell carcinoma of the pituitary.