| Complications of pregnancy and transplacental transmission of relapsing-fever borreliosis. | |
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MedLine Citation:
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PMID: 17054065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relapsing-fever borreliosis caused by Borrelia duttonii is a common cause of complications of pregnancy, miscarriage, and neonatal death in sub-Saharan Africa. We established a murine model of gestational relapsing fever infection for the study of the pathological development of these complications. We demonstrate that B. duttonii infection during pregnancy results in intrauterine growth retardation, as well as placental damage and inflammation, impaired fetal circulation, and decreased maternal hemoglobin levels. We show that spirochetes frequently cross the maternal-fetal barrier, resulting in congenital infection. Furthermore, we compared the severity of infection in pregnant and nonpregnant mice and show that pregnancy has a protective effect. This model closely parallels the consequences of human gestational infection, and our results provide insight into the mechanisms behind the complications of pregnancy that have been reported in human relapsing-fever infection. |
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Authors:
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Christer Larsson; Marie Andersson; Betty P Guo; Annika Nordstrand; Inga Hagerstrand; Sara Carlsson; Sven Bergstrom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-03 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 194 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-20 Completed Date: 2006-12-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1367-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Molecular Biology, Umea University, Umea, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteremia Borrelia* Disease Models, Animal Female Fetal Diseases / microbiology*, pathology Fetal Growth Retardation Fetal Weight Hemoglobins / analysis Histocytochemistry Infectious Disease Transmission, Vertical* Mice Mice, Inbred C3H Placenta / microbiology*, pathology Placental Circulation Pregnancy Pregnancy Complications, Infectious* / microbiology, pathology Relapsing Fever / microbiology, pathology, transmission* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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