Document Detail

Complications of pregnancy and transplacental transmission of relapsing-fever borreliosis.
MedLine Citation:
PMID:  17054065     Owner:  NLM     Status:  MEDLINE    
Relapsing-fever borreliosis caused by Borrelia duttonii is a common cause of complications of pregnancy, miscarriage, and neonatal death in sub-Saharan Africa. We established a murine model of gestational relapsing fever infection for the study of the pathological development of these complications. We demonstrate that B. duttonii infection during pregnancy results in intrauterine growth retardation, as well as placental damage and inflammation, impaired fetal circulation, and decreased maternal hemoglobin levels. We show that spirochetes frequently cross the maternal-fetal barrier, resulting in congenital infection. Furthermore, we compared the severity of infection in pregnant and nonpregnant mice and show that pregnancy has a protective effect. This model closely parallels the consequences of human gestational infection, and our results provide insight into the mechanisms behind the complications of pregnancy that have been reported in human relapsing-fever infection.
Christer Larsson; Marie Andersson; Betty P Guo; Annika Nordstrand; Inga Hagerstrand; Sara Carlsson; Sven Bergstrom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-03
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  194     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2006-12-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1367-74     Citation Subset:  AIM; IM    
Department of Molecular Biology, Umea University, Umea, Sweden.
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MeSH Terms
Disease Models, Animal
Fetal Diseases / microbiology*,  pathology
Fetal Growth Retardation
Fetal Weight
Hemoglobins / analysis
Infectious Disease Transmission, Vertical*
Mice, Inbred C3H
Placenta / microbiology*,  pathology
Placental Circulation
Pregnancy Complications, Infectious* / microbiology,  pathology
Relapsing Fever / microbiology,  pathology,  transmission*
Reg. No./Substance:

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