| Complications of massive transfusion. | |
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MedLine Citation:
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PMID: 20051407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Massive transfusion (MT) is a lifesaving treatment of hemorrhagic shock, but can be associated with significant complications. The lethal triad of acidosis, hypothermia, and coagulopathy associated with MT is associated with a high mortality rate. Other complications include hypothermia, acid/base derangements, electrolyte abnormalities (hypocalcemia, hypomagnesemia, hypokalemia, hyperkalemia), citrate toxicity, and transfusion-associated acute lung injury. Blood transfusion in trauma, surgery, and critical care has been identified as an independent predictor of multiple organ failure, systemic inflammatory response syndrome, increased infection, and increased mortality in multiple studies. Once definitive control of hemorrhage has been established, a restrictive approach to blood transfusion should be implemented to minimize further complications. |
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Authors:
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Kristen C Sihler; Lena M Napolitano |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Chest Volume: 137 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-06 Completed Date: 2010-02-02 Revised Date: 2010-04-06 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 209-20 Citation Subset: AIM; IM |
Affiliation:
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University of Michigan School of Medicine, Ann Arbor, MI 48109-0033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation* Blood Coagulation Disorders / blood, etiology* Blood Transfusion / adverse effects*, mortality Humans Multiple Organ Failure / blood, etiology* Prognosis Risk Factors Shock, Hemorrhagic / therapy* Survival Rate Systemic Inflammatory Response Syndrome / blood, etiology* Thrombocytopenia / blood, etiology* |
| Comments/Corrections | |
Erratum In:
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Chest. 2010 Mar;137(3):744 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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