| Complications of in vitro fertilization with intracytoplasmic sperm injection in human immunodeficiency virus serodiscordant couples. | |
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MedLine Citation:
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PMID: 12756584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Our experience with complications related to in vitro fertilization (IVF), particularly ovarian hyperstimulation syndrome (OHSS) and higher-order multiple gestations, in human immunodeficiency virus (HIV) serodiscordant couples undergoing IVF with intracytoplasmic sperm injection (ICSI) is presented. METHODS: We retrospectively evaluated 132 consecutive IVF-ICSI cycles and the ensuing 43 pregnancies in 74 HIV-seropositive male discordant couples. The diagnosis of moderate and severe OHSS was based on clinical criteria. Higher-order multiple gestations were defined as viable triplets or greater by the end of the first trimester verified by ultrasonography. RESULTS: The incidence of moderate and severe OHSS was 4.5% of initiated IVF cycles. Seven of the 43 (16.3%) pregnancies were higher-order multiple gestations (1 quadruplet and 6 triplet pregnancies), resulting in the delivery of 3 sets of triplets and 3 sets of twins, with an ongoing twin pregnancy. Four patients had undergone multifetal pregnancy reduction to twins. There were no seroconversions in the women and the infants. CONCLUSION: HIV serodiscordant couples undergoing fertility treatment with IVF-ICSI should be made particularly aware of the risks of higher-order multiple gestations and OHSS. |
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Authors:
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Joseph E Peña; Melvin H Thornton; Mark V Sauer |
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Publication Detail:
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Type: Journal Article Date: 2003-05-20 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 268 ISSN: 0932-0067 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-27 Completed Date: 2004-03-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 198-201 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Columbia-Presbyterian Medical Center, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 16-28, New York, NY 10032, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fathers* Female Fertilization in Vitro* / adverse effects, methods HIV Infections* / transmission HIV Seronegativity HIV Seropositivity Humans Incidence Infectious Disease Transmission, Vertical / prevention & control Male Medical Records New York / epidemiology Ovarian Hyperstimulation Syndrome / epidemiology*, etiology Pregnancy Pregnancy Outcome Pregnancy, Multiple / statistics & numerical data Retrospective Studies Sperm Injections, Intracytoplasmic |
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