Document Detail

Complications of in vitro fertilization with intracytoplasmic sperm injection in human immunodeficiency virus serodiscordant couples.
MedLine Citation:
PMID:  12756584     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Our experience with complications related to in vitro fertilization (IVF), particularly ovarian hyperstimulation syndrome (OHSS) and higher-order multiple gestations, in human immunodeficiency virus (HIV) serodiscordant couples undergoing IVF with intracytoplasmic sperm injection (ICSI) is presented. METHODS: We retrospectively evaluated 132 consecutive IVF-ICSI cycles and the ensuing 43 pregnancies in 74 HIV-seropositive male discordant couples. The diagnosis of moderate and severe OHSS was based on clinical criteria. Higher-order multiple gestations were defined as viable triplets or greater by the end of the first trimester verified by ultrasonography. RESULTS: The incidence of moderate and severe OHSS was 4.5% of initiated IVF cycles. Seven of the 43 (16.3%) pregnancies were higher-order multiple gestations (1 quadruplet and 6 triplet pregnancies), resulting in the delivery of 3 sets of triplets and 3 sets of twins, with an ongoing twin pregnancy. Four patients had undergone multifetal pregnancy reduction to twins. There were no seroconversions in the women and the infants. CONCLUSION: HIV serodiscordant couples undergoing fertility treatment with IVF-ICSI should be made particularly aware of the risks of higher-order multiple gestations and OHSS.
Joseph E Peña; Melvin H Thornton; Mark V Sauer
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Publication Detail:
Type:  Journal Article     Date:  2003-05-20
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  268     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-27     Completed Date:  2004-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  198-201     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Columbia-Presbyterian Medical Center, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 16-28, New York, NY 10032, USA.
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MeSH Terms
Fertilization in Vitro* / adverse effects,  methods
HIV Infections* / transmission
HIV Seronegativity
HIV Seropositivity
Infectious Disease Transmission, Vertical / prevention & control
Medical Records
New York / epidemiology
Ovarian Hyperstimulation Syndrome / epidemiology*,  etiology
Pregnancy Outcome
Pregnancy, Multiple / statistics & numerical data
Retrospective Studies
Sperm Injections, Intracytoplasmic

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