| Complications of essential amino acid hyperalimentation in children with acute renal failure. | |
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MedLine Citation:
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PMID: 6767049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic effects of intravenous hyperalimentation, using an essential amino acid (EAA) and glucose solution, were evaluated in 2 children with acute renal failure. Hyperammonemia and hyperchloremic metabolic acidosis associated with elevated plasma methionine and depressed plasma citrulline, ornithine, arginine, and histidine levels complicated the nutritional therapy. Initial infusion of a complete amino acid (CAA) solution was not associated with these aberrations and reintroduction of a CAA solution after the EAA trial resulted in a progressive amelioration of or complete recovery from these metabolic disturbances. It is likely that the hyperammonemia was due to an arginine deficiency, while excess methionine and presumably sulfate production may have contributed to the hyperchloremic metabolic acidosis in these two children. |
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Authors:
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K J Motil; W E Harmon; W E Grupe |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 4 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1980 Jan-Feb |
Date Detail:
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Created Date: 1980-05-23 Completed Date: 1980-05-23 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 32-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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etiology* Amino Acids / administration & dosage Amino Acids, Essential / administration & dosage, adverse effects* Ammonia / blood* Child, Preschool Histidine / administration & dosage Humans Infant Kidney Failure, Acute / metabolism* Male Nitrogen / administration & dosage Nutritional Requirements Parenteral Nutrition / adverse effects* Parenteral Nutrition, Total / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Essential; 71-00-1/Histidine; 7664-41-7/Ammonia; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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