Document Detail


Complications and conversions in myeloproliferative disorders: an analysis of 356 cases.
MedLine Citation:
PMID:  12411064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the complications and conversions in myeloproliferative disorders (MPD). METHODS: Three hundred and fifty six patients with MPD were reviewed, including 78 with etiologic thrombocythemia (ET), 93 with primary myelofibrosis (MF), 185 with polythythemia vera (PV). The clinical observation, follow-up, analysis with SPSS statistic software were performed. RESULTS: Out of the 356 cases, 101 (28.5%) developed thromboembolic events, 81 (22.8%) hemorrhage, 60 (16.9%) hypertension, 20 (5.6%) coronary heart disease, 3 (0.8%) hemolysis and 1 (0.3%) gastrointestinal ulcer, 2 (0.6%) calculus and 1 (0.3%) bone marrow necrosis. Twenty four patients (6.7%) developed MF (9 in ET, 15 in PV), 2 (0.6%) erythrocytosis (1 in ET, 1 in MF), 3 (0.8%) thrombocythemia (all in PV), 5 (1.4%) acute leukemia (2 in ET, 3 in MF) and 1 (0.3%) multiple myeloma (in ET). Eleven cases (3.1%) died, 5 (1.4%) from acute leukemia, 2 (0.6%) fatal hemorrhages, 1 (0.3%) each myocardial infarction and infectious shock, 2 (0.6%) unknown causes. CONCLUSION: Embolism and bleeding were the main complications in MPD. Conversions among ET, MF and PV hematological malignancies could occur.
Authors:
Yi Wang; Anlan Zuo; Yinghui Liu; Bingcheng Liu; Changlai Hao; Lihong Wang; Xueli Zhou; Linsheng Qian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi     Volume:  23     ISSN:  0253-2727     ISO Abbreviation:  Zhonghua Xue Ye Xue Za Zhi     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2002-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8212398     Medline TA:  Zhonghua Xue Ye Xue Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  314-7     Citation Subset:  IM    
Affiliation:
Institute of Hematology, CAMS and PUMC, Tianjin 300020, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Humans
Male
Middle Aged
Myeloproliferative Disorders / complications*,  mortality

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