Document Detail

Complications associated with sickle cell trait: a brief narrative review.
MedLine Citation:
PMID:  19393983     Owner:  NLM     Status:  MEDLINE    
Sickle cell trait occurs in approximately 300 million people worldwide, with the highest prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign carrier state with relative protection against severe malaria, sickle cell trait occasionally can be associated with significant morbidity and mortality. Sickle cell trait is exclusively associated with rare but often fatal renal medullary cancer. Current cumulative evidence is convincing for associations with hematuria, renal papillary necrosis, hyposthenuria, splenic infarction, exertional rhabdomyolysis, and exercise-related sudden death. Sickle cell trait is probably associated with complicated hyphema, venous thromboembolic events, fetal loss, neonatal deaths, and preeclampsia, and possibly associated with acute chest syndrome, asymptomatic bacteriuria, and anemia in pregnancy. There is insufficient evidence to suggest an independent association with retinopathy, cholelithiasis, priapism, leg ulcers, liver necrosis, avascular necrosis of the femoral head, and stroke. Despite these associations, the average life span of individuals with sickle cell trait is similar to that of the general population. Nonetheless, given the large number of people with sickle cell trait, it is important that physicians be aware of these associations.
Geoffrey Tsaras; Amma Owusu-Ansah; Freda Owusua Boateng; Yaw Amoateng-Adjepong
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-04-24
Journal Detail:
Title:  The American journal of medicine     Volume:  122     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-12     Citation Subset:  AIM; IM    
Combined Medicine-Pediatrics, Bridgeport Hospital, Yale New Haven Health, Bridgeport, Connecticut 06610, USA.
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MeSH Terms
Africa South of the Sahara / epidemiology
Carcinoma, Medullary / etiology
Chest Pain / etiology
Death, Sudden / etiology
Fatigue / etiology
Hematuria / etiology
Hyphema / etiology
Kidney Neoplasms / etiology
Kidney Papillary Necrosis / etiology
Pre-Eclampsia / etiology
Pregnancy Complications, Hematologic / etiology
Rhabdomyolysis / etiology
Risk Factors
Sickle Cell Trait / complications*,  epidemiology*,  mortality
Splenic Infarction / etiology
Venous Thromboembolism / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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