Document Detail


Complications associated with intra-arterial BCNU administered in combination with vincristine and procarbazine for the treatment of malignant brain tumors.
MedLine Citation:
PMID:  6481425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have used intra-arterial (i.a.) 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) either alone or as part of adjuvant chemotherapy in patients with malignant brain tumors over a 3 year period (1979-1982). The i.a. BCNU technique was used 111 times to infuse 134 arteries in 37 patients. These patients, 28 cases with glial tumor and 9 cases with brain metastasis, received i.a. BCNU in combination with Vincristine and Procarbazine every 6 weeks. Complications encountered were transient and included: periorbital erythralgia or occipital-nuchal pain in 23 (62%), mild confusion and disorientation in 14 (38%), and ipsilateral conjunctival edema in 10 (27%). Reversible myelosuppression was not found. Our findings suggest that BCNU (100 mg/M2) may be given by i.a. infusion in combination chemotherapy without persistent severe untoward effects with a cumulative dose of 700 mg/M2.
Authors:
A M Bremer; E Kleriga; T Q Nguyen; R Balsys; H M Northup; N Gonzalez; P Duarte; R I Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  2     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols*
Brain Neoplasms / drug therapy*,  secondary
Carmustine / administration & dosage
Carotid Arteries
Carotid Artery, Internal
Child
Child, Preschool
Female
Glioma / drug therapy*
Humans
Infusions, Intra-Arterial
Male
Middle Aged
Procarbazine / administration & dosage
Vertebral Artery
Vincristine / administration & dosage
Chemical
Reg. No./Substance:
154-93-8/Carmustine; 57-22-7/Vincristine; 671-16-9/Procarbazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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