| Complications associated with intra-arterial BCNU administered in combination with vincristine and procarbazine for the treatment of malignant brain tumors. | |
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MedLine Citation:
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PMID: 6481425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have used intra-arterial (i.a.) 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) either alone or as part of adjuvant chemotherapy in patients with malignant brain tumors over a 3 year period (1979-1982). The i.a. BCNU technique was used 111 times to infuse 134 arteries in 37 patients. These patients, 28 cases with glial tumor and 9 cases with brain metastasis, received i.a. BCNU in combination with Vincristine and Procarbazine every 6 weeks. Complications encountered were transient and included: periorbital erythralgia or occipital-nuchal pain in 23 (62%), mild confusion and disorientation in 14 (38%), and ipsilateral conjunctival edema in 10 (27%). Reversible myelosuppression was not found. Our findings suggest that BCNU (100 mg/M2) may be given by i.a. infusion in combination chemotherapy without persistent severe untoward effects with a cumulative dose of 700 mg/M2. |
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Authors:
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A M Bremer; E Kleriga; T Q Nguyen; R Balsys; H M Northup; N Gonzalez; P Duarte; R I Miller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 2 ISSN: 0167-594X ISO Abbreviation: J. Neurooncol. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-11-01 Completed Date: 1984-11-01 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols* Brain Neoplasms / drug therapy*, secondary Carmustine / administration & dosage Carotid Arteries Carotid Artery, Internal Child Child, Preschool Female Glioma / drug therapy* Humans Infusions, Intra-Arterial Male Middle Aged Procarbazine / administration & dosage Vertebral Artery Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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154-93-8/Carmustine; 57-22-7/Vincristine; 671-16-9/Procarbazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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