Document Detail

Complications following linear accelerator based stereotactic radiation for cerebral arteriovenous malformations.
MedLine Citation:
PMID:  19796884     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Primarily, gamma knife centers are predominant in publishing results on arteriovenous malformations (AVM) treatments including reports on risk profile. However, many patients are treated using a linear accelerator-most of these at smaller centers. Because this setting is different from a large gamma knife center, the risk profile at Linac departments could be different from the reported experience. Prescribed radiation doses are dependent on AVM volume. This study details results from a medium sized Linac department center focusing on risk profiles. METHOD AND MATERIALS: A database was searched for all patients with AVMs. We included 50 consecutive patients with a minimum of 24 months follow-up (24-51 months). RESULTS: AVM occlusion was verified in 78% of patients (39/50). AVM occlusion without new deficits (excellent outcome) was obtained in 44%. Good or fair outcome (AVM occlusion with mild or moderate new deficits) was seen in 30%. Severe complications after AVM occlusion occurred in 4% with a median interval of 15 months after treatment (range, 1-26 months). CONCLUSIONS: We applied an AVM grading score developed at the Mayo Clinic to predict probable outcome after radiosurgery in a large patient population treated with Gamma knife. A cutoff above and below a score of 1.5 could not discriminate between the likelihood of having an excellent outcome (approximately 45%). The chance of having an excellent or good outcome was slightly higher in patients with an AVM score below 1.5 (64% vs. 57%).
Jane Skj?th-Rasmussen; Henrik Roed; Lars Ohlhues; Bo Jespersen; Marianne Juhler
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Publication Detail:
Type:  Journal Article     Date:  2009-09-30
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  77     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Intracranial Arteriovenous Malformations / surgery*
Middle Aged
Particle Accelerators
Radiosurgery / adverse effects*,  instrumentation,  methods
Radiotherapy Dosage
Risk Factors
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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