Document Detail


Complications, adverse events, and additional intraocular surgery 1 year after cataract surgery in the infant Aphakia Treatment Study.
MedLine Citation:
PMID:  21925737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implantation.
DESIGN: Prospective, randomized clinical trial.
PARTICIPANTS: The Infant Aphakia Treatment Study (IATS) is a randomized, multicenter (n = 12) clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with unilateral congenital cataract.
INTERVENTION: Infants underwent cataract surgery with or without placement of an IOL.
MAIN OUTCOME MEASURES: The rate, character, and severity of intraoperative complications (ICs), adverse events (AEs), and additional intraocular surgeries (AISs) during the first postoperative year in the 2 groups were analyzed.
RESULTS: There were more patients with ICs (28% vs. 11%; P = 0.031), AEs (77% vs. 25%; P<0.0001), and AISs (63% vs. 12%; P<0.0001) in the IOL group than the contact lens group. Iris prolapse was the most common IC. The most common AE was visual axis opacification, and the most common additional intraocular reoperation was a clearing of visual axis opacification.
CONCLUSIONS: The rates of ICs, AEs, and AISs 1 year after surgery were numerically higher in the IOL group, but their functional impact does not clearly favor either treatment group.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Authors:
David A Plager; Michael J Lynn; Edward G Buckley; M Edward Wilson; Scott R Lambert;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-09-16
Journal Detail:
Title:  Ophthalmology     Volume:  118     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-05     Completed Date:  2012-01-26     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2330-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
Affiliation:
Indiana University Medical Center, Indianapolis, Indiana 46202, USA. dplager@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Aphakia, Postcataract / physiopathology,  therapy*
Capsule Opacification / etiology,  surgery
Cataract / congenital*
Cataract Extraction*
Contact Lenses*
Humans
Infant
Infant, Newborn
Intraoperative Complications*
Lens Implantation, Intraocular*
Postoperative Complications*
Prospective Studies
Reoperation
Visual Acuity / physiology
Grant Support
ID/Acronym/Agency:
EY06360/EY/NEI NIH HHS; R21 EY011987-01A1/EY/NEI NIH HHS; U10 EY013272-01A2/EY/NEI NIH HHS; U10 EY013287/EY/NEI NIH HHS; U10 EY13272/EY/NEI NIH HHS
Investigator
Investigator/Affiliation:
Scott R Lambert / ; Lindreth DuBois / ; Michael Lynn / ; Betsy Bridgman / ; Marianne Celano / ; Julia Cleveland / ; George Cotsonis / ; Carey Drews-Botsch / ; Nana Freret / ; Lu Lu / ; Azhar Nizam / ; Seegar Swanson / ; Thandeka Tutu / ; E Eugenie Hartmann / ; Clara Edwards / ; Claudio Busettini / ; Samuel Hayley / ; Scott R Lambert / ; Edward G Buckley / ; David A Plager / ; M Edward Wilson / ; Michael Lynn / ; Lindreth DuBois / ; Carolyn Drews-Botsch / ; E Eugenie Hartmann / ; Donald F Everett / ; Buddy Russell / ; Michael Ward / ; M Edward Wilson / ; Margaret Bozic / ; Deborah K VanderVeen / ; Theresa A Mansfield / ; Kathryn Bisceglia Miller / ; Stephen P Christiansen / ; Erick D Bothun / ; Ann Holleschau / ; Jason Jedlicka / ; Patricia Winters / ; Jacob Lang / ; Elias I Traboulsi / ; Susan Crowe / ; Heather Hasley Cimino / ; Kimberly G Yen / ; Maria Castanes / ; Alma Sanchez / ; Shirley York / ; David T Wheeler / ; Ann U Stout / ; Paula Rauch / ; Kimberly Beaudet / ; Pam Berg / ; Scott R Lambert / ; Amy K Hutchinson / ; Lindreth DuBois / ; Rachel Robb / ; Marla J Shainberg / ; Edward G Buckley / ; Sharon F Freedman / ; Lois Duncan / ; B W Phillips / ; John T Petrowski / ; David Morrison / ; Sandy Owings / ; Ron Biernacki / ; Christine Franklin / ; David A Plager / ; Daniel E Neely / ; Michele Whitaker / ; Donna Bates / ; Dana Donaldson / ; Stacey Kruger / ; Charlotte Tibi / ; Susan Vega / ; David R Weakley / ; David R Stager / ; Joost Felius / ; Clare Dias / ; Debra L Sager / ; Todd Brantley / ; Robert Hardy / ; Eileen Birch / ; Ken Cheng / ; Richard Hertle / ; Craig Kollman / ; Marshalyn Yeargin- Allsopp / ; Cyd McDowell / ; Donald F Everett / ; Allen Beck /
Comments/Corrections
Comment In:
Ophthalmology. 2012 Jul;119(7):1503-4;author reply 1504-5   [PMID:  22749102 ]

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