| Complicated pain management in a CYP450 2D6 poor metabolizer. | |
| | |
MedLine Citation:
|
PMID: 17986163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We describe the case of a patient with significant adverse effects from posttraumatic analgesic therapy with opioid analgesics who was found by microarray analysis to have a CYP2D6 genotype predictive of a poor metabolizer phenotype. In addition to her poor tolerance and limited response to opioid analgesics, she developed further discomfort when the antiemetic promethazine was administered to treat her gastrointestinal adverse effects. In our discussion we review the literature about the clinical impact of CYP450 2D6 polymorphisms in treatment with the commonly used opioid analgesics codeine, oxycodone, hydrocodone, hydromorphone, and morphine, as well as the antiemetic promethazine. The case we present, as well as the literature we review, demonstrates the clinical utility of CYP2D6 genotyping in patients with adverse effects from analgesia therapy. |
| | |
Authors:
|
Adriana Foster; Elizabeth Mobley; Zixuan Wang |
Related Documents
:
|
11215153 - The effects of zolpidem and zopiclone on daytime sleepiness and psychomotor performance. 7582873 - Effect of apolipoprotein e polymorphism on fasting retinyl palmitate level. 19584633 - Cor pulmonale due to congenital central hypoventilation syndrome presenting in adolesce... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-06 |
Journal Detail:
|
Title: Pain practice : the official journal of World Institute of Pain Volume: 7 ISSN: 1533-2500 ISO Abbreviation: Pain Pract Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-20 Completed Date: 2007-12-21 Revised Date: 2009-01-16 |
Medline Journal Info:
|
Nlm Unique ID: 101130835 Medline TA: Pain Pract Country: United States |
Other Details:
|
Languages: eng Pagination: 352-6 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA. afoster@mcg.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analgesics, Opioid
/
adverse effects*,
pharmacokinetics* Antiemetics / adverse effects, pharmacokinetics Cytochrome P-450 CYP2D6 / genetics*, metabolism* Female Humans Middle Aged Pain / drug therapy* Promethazine / adverse effects, pharmacokinetics Spinal Fractures / complications Thoracic Vertebrae / injuries |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 0/Antiemetics; 60-87-7/Promethazine; EC 1.14.14.1/Cytochrome P-450 CYP2D6 |
| Comments/Corrections | |
Comment In:
|
Pain Pract. 2008 Jul-Aug;8(4):329; author reply 330
[PMID:
18507781
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The burden of headache in neurology outpatient clinics in Turkey.
Next Document: Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: ...