| Complicated migraine studied by phosphorus magnetic resonance spectroscopy. | |
| | |
MedLine Citation:
|
PMID: 2272097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The brain and skeletal muscle of eight adult patients with migraine with prolonged auras or migraine strokes leaving a permanent hemianopic defect were studied by phosphorus magnetic resonance spectroscopy. Biochemical assays performed on muscle biopsy and platelets had revealed abnormal mitochondrial enzyme activities. Brain magnetic resonance spectroscopy showed an abnormally low phosphocreatine to inorganic phosphate ratio in all patients, apparently due to decreased phosphocreatine and increased inorganic phosphate contents. Muscle phosphorus magnetic resonance spectroscopy showed low recovery from exercise in seven patients. Three patients had an increased phosphocreatine/inorganic phosphate ratio at rest, and the exercise transfer characteristics were abnormal in four patients for relatively low levels of exercise. The mitochondrial metabolic defects present in platelets and muscle of complicated migraine patients are therefore also expressed in the brain. |
| | |
Authors:
|
B Barbiroli; P Montagna; P Cortelli; P Martinelli; T Sacquegna; P Zaniol; E Lugaresi |
Related Documents
:
|
18071957 - Effect of soft drinks on proximal plaque ph at normal and low salivary secretion rates. 2125637 - A case of mitochondrial myopathy, lactic acidosis and complex i deficiency. 9477067 - Fructose-1,6-bisphosphate preserves adenosine triphosphate but not intracellular ph dur... 18270377 - 31p mr spectroscopic assessment of muscle in patients with myasthenia gravis before and... 6089857 - Antagonism of alcuronium with edrophonium or neostigmine. 18187617 - The growth hormone response to repeated bouts of sprint exercise with and without suppr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cephalalgia : an international journal of headache Volume: 10 ISSN: 0333-1024 ISO Abbreviation: Cephalalgia Publication Date: 1990 Oct |
Date Detail:
|
Created Date: 1991-02-25 Completed Date: 1991-02-25 Revised Date: 2008-02-11 |
Medline Journal Info:
|
Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 263-72 Citation Subset: IM |
Affiliation:
|
Istituto di Clinica Neurologica, Università di Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Brain / pathology Female Humans Magnetic Resonance Imaging / methods* Middle Aged Migraine Disorders / diagnosis* Muscles / pathology Phosphorus / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
7723-14-0/Phosphorus |
| Comments/Corrections | |
Comment In:
|
Cephalalgia. 1991 Jul;11(3):161-2
[PMID:
1889074
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Contralateral trigeminal dysaesthesias associated with second cervical nerve compression: a case rep...
Next Document: Drug delivery systems for antitumor activation of macrophages.