| Complicated diverticulitis: is it time to rethink the rules? | |
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MedLine Citation:
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PMID: 16192818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Much of our knowledge and treatment of complicated diverticulitis (CD) are based on outdated literature reporting mortality rates of 10%. Practice parameters recommend elective resection after 2 episodes of diverticulitis to reduce morbidity and mortality. The aim of this study is to update our understanding of the morbidity, mortality, characteristics, and outcomes of CD. METHODS: Three hundred thirty-seven patients hospitalized for CD were retrospectively analyzed. Characteristics and outcomes were determined using chi-squared and Fisher exact tests. RESULTS: Mean age of patients was 65 years. Seventy percent had one or more comorbidities. A total of 46.6% had a history of at least one prior diverticulitis episode, whereas 53.4% presented with CD as their first episode. Overall mortality rate was 6.5% (86.4% associated with perforation, 9.5% anastomotic leak, 4.5% patient managed nonoperatively). A total of 89.5% of the perforation patients who died had no history of diverticulitis. Steroid use was significantly associated with perforation rates as well as mortality (P< 0.001 and P = 0.002). Comorbidities such as diabetes, collagen-vascular disease, and immune system compromise were also highly associated with death (P = 0.006, P = 0.009, and P = 0.003, respectively). Overall morbidity was 41.4%. Older age, gender, steroids, comorbidities, and perforation were significantly associated with morbidity. CONCLUSION: Today, mortality from CD excluding perforation is reduced compared with past data. This, coupled with the fact that the majority of these patients presented with CD as their first episode, calls into question the current practice of elective resection as a stratagem for reducing mortality. Immunocompromised patients may benefit from early resection. New prospective data is needed to redefine target groups for prophylactic resection. |
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Authors:
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Jennifer Chapman; Michael Davies; Bruce Wolff; Eric Dozois; Deron Tessier; Jeffrey Harrington; Dirk Larson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Annals of surgery Volume: 242 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-29 Completed Date: 2005-11-08 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: United States |
Other Details:
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Languages: eng Pagination: 576-81; discussion 581-3 Citation Subset: AIM; IM |
Affiliation:
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Division of Colon and Rectal Surgery, Mayo Clinic and Mayo Foundation, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Colectomy Colonic Diseases / complications*, mortality, surgery Diverticulitis / complications*, mortality, surgery Female Follow-Up Studies Gastrointestinal Hemorrhage / complications, mortality Humans Intestinal Obstruction / complications, mortality Intestinal Perforation / complications, mortality Male Middle Aged Peritonitis / etiology*, mortality Retrospective Studies Risk Factors Survival Rate / trends Treatment Outcome |
| Comments/Corrections | |
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