| Compliance, tolerability and safety of two antioxidant-rich diets: a randomised controlled trial in male smokers. | |
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MedLine Citation:
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PMID: 21806852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that antioxidants attenuate oxidative stress and prevent oxidative stress-related diseases. Paradoxically, randomised controlled trials (RCT) using pharmacological doses of antioxidant supplements have demonstrated harmful effects in smokers. The aim of the present study was to test the compliance, tolerability and safety of two food-based antioxidant-rich diets in smokers. One of the diets provided antioxidants at levels similar to that used in RCT using supplements which previously have generated harmful effects. The present study followed a randomised, parallel-arm dietary intervention for 8 weeks (n 102) in male smokers (age ≥ 45 years). Participants were randomised to either antioxidant-rich diet, kiwi fruit or control groups. The antioxidant-rich foods provided about 300 mmol antioxidants/week from a wide range of plant-based food items. The kiwi fruit group consumed three kiwi fruits/d. Compliance to both diets was good. Only mild, undesirable events were reported by a minority of the participants. The safety of both diets was demonstrated as no potentially harmful or pro-oxidative effects were observed. In the antioxidant-rich diet group, the mean intake of antioxidants increased from 30 mmol/d at baseline to 62 mmol/d during the intervention. In conclusion, we have demonstrated that male smokers can comply with two food-based antioxidant-rich diets. Furthermore, the present study is the first to demonstrate the tolerability and safety of dietary antioxidants at levels similar to dosages provided in RCT using supplements. Such diets may be useful in future studies investigating whether dietary antioxidants may reduce oxidative stress and related diseases. |
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Authors:
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Anette Karlsen; Mette Svendsen; Ingebjørg Seljeflot; Mary-Ann Sommernes; Joseph Sexton; Asgeir Brevik; Iris Erlund; Mauro Serafini; Nasser Bastani; Siv Fagertun Remberg; Grethe I Borge; Monica Hauger Carlsen; Siv Kjølsrud Bøhn; Mari C Myhrstad; Lars O Dragsted; Asim K Duttaroy; Karin Haffner; Petter Laake; Christan A Drevon; Harald Arnesen; Andrew Collins; Serena Tonstad; Rune Blomhoff |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of nutrition Volume: 106 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-02 Completed Date: 2011-09-29 Revised Date: 2012-03-11 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 557-71 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00520819 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actinidia
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adverse effects Aged Antioxidants / administration & dosage, adverse effects*, analysis Diet / adverse effects* Diet Records Fruit / adverse effects Humans Male Middle Aged Norway Oxidative Stress* Patient Compliance / statistics & numerical data* Questionnaires Smoking* / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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