| Compliance aids and medicine stability: new evidence of quality assurance. | |
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MedLine Citation:
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PMID: 19149527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although increasing use of compliance aids is resulting in improved clinical outcomes for patients, the stability of some drugs being repackaged into these aids is being questioned. This is due to the fact that despite their widespread use, there is limited availability of relevant stability data. This review presents clinical evidence for repackaging into Dose Administration Aids (DAAs), the Australian Pharmaceutical Advisory Committee and other guidelines on general stability issues related to repackaging and a summary of evidence for stability studies conducted in the practice. For frusemide and prochlorperazine chosen as candidates for study because of their light sensitivity, while discoloration on light exposure rendered them unacceptable for patient use, precautions in repackaging and patient counselling can easily overcome this problem. In the case of sodium valproate however, hygroscopicity results in these tablets being unusable after exposure to accelerated storage conditions. In the absence of specific data on the stability of drug products repackaged into compliance aids, the guidelines, practical recommendations for repackaging and the management of compliance aids put forward in this article provide the pharmacist with the tools to make an informed decision on this process. |
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Authors:
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Beverley Dawn Glass; Alison Haywood; Victoria Llewelyn; Martina Mangan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current drug safety Volume: 4 ISSN: 1574-8863 ISO Abbreviation: - Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101270895 Medline TA: Curr Drug Saf Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 74-8 Citation Subset: IM |
Affiliation:
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School of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD, Australia. Beverley.Glass@jcu.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Australia Drug Packaging / standards* Drug Stability* Drug Storage Guidelines as Topic Humans Medication Adherence* Pharmaceutical Preparations / chemistry, standards Quality Control Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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