Document Detail

Complexity reduction of chromatin architecture in macula densa cells during mouse postnatal development.
MedLine Citation:
PMID:  23088294     Owner:  NLM     Status:  Publisher    
AIM: To determine whether complexity of chromatin structure in kidney macula densa cells (MDCs) decreases during postnatal development in mice. METHODS: The levels of chromatin structural complexity were measured by determining fractal dimension of MDC nuclei. Kidney tissue was obtained from the total of 32 male Swiss albino mice divided into 4 age groups (n=8): newborn (0 days), 10 days old, 20 days old and 30 days old. For total of 640 MDC chromatin structures, fractal dimension, lacunarity, as well as parameters of Grey level co-occurrence matrix (GLCM) texture were determined. RESULTS: Chromatin fractal dimension in animals aged 10 days, 20 days and 30 days was significantly lower (p<0.05, p<0.01 and p<0.001, respectively), compared to newborn mice. This complexity reduction of chromatin architecture is in accordance with previously published studies which detected generalized and sustained loss of both tissue and cell complexity during aging. The loss of complexity was texture-independent, since there was no statistically significant difference (p>0.05) in both chromatin angular second moment and inverse difference moment between the age groups. CONCLUSION: Our results indicate that age-related nuclear intrinsic factors which do not influence chromatin texture may have an important role in MDC postnatal development.
Igor Pantic; Gordana Basta-Jovanovic; Vesna Starcevic; Jovana Paunovic; Slavica Suzic; Zvezdana Kojic; Senka Pantic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-23
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, isegradska 26/II, 11129, Belgrade, Serbia.
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